A team at the University of California, Los Angeles (UCLA) found that injured kidneys produce ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), a protein that hydrolyzes extracellular ATP into AMP and pyrophosphate, and that impedes tissue repair.

Acute kidney injury (AKI), although sometimes reversible, is associated with an increased risk of chronic kidney disease (CKD) and progression to end-stage renal disease (ESRD). Reactive oxygen species (ROS) contribute to maladaptive repair and progression to CKD.

Researchers from China hypothesized that Takeda G protein-coupled receptor 5 (TGR5), also known as G-protein coupled bile acid receptor 1, could have therapeutic potential in acute kidney injury by inhibiting ferroptosis.

Heeding the recommendation of an independent data monitoring committee, Calcimedica Inc. said it is discontinuing the phase II study testing calcium release-activated calcium channel inhibitor Auxora in patients with acute kidney injury with associated acute hypoxemic respiratory failure.

Researchers from the Children’s Hospital of Nanjing Medical University have identified WW domain-containing E3 ubiquitin protein ligase 2 (WWP2) as a key player in the progression from acute kidney injury (AKI) chronic kidney disease (CKD).

German researchers have cracked the decades-long mystery of why males are more susceptible to acute kidney injury than females, demonstrating that estrogen has a protective effect in females.

German researchers have cracked the decades-long mystery of why males are more susceptible to acute kidney injury than females, demonstrating that estrogen has a protective effect in females.

German researchers have cracked the decades-long mystery of why males are more susceptible to acute kidney injury than females, demonstrating that estrogen has a protective effect in females.