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Articles Tagged with ''neuropathic pain''

Neurology/psychiatric

CIRM grant supports Navega’s gene therapy for chronic pain

Feb. 5, 2025

Navega Therapeutics Inc. has received a $4 million Translational Science grant from the California Institute for Regenerative Medicine (CIRM) to support its work addressing neuropathic pain. The grant will fund the final preclinical development studies of NT-Z001 leading to an IND submission.

Neurology/psychiatric

Humanwell Healthcare identifies new angiotensin AT2 receptor antagonists

Jan. 14, 2025

Humanwell Healthcare (Group) Co. Ltd. has developed new heterocyclic compounds acting as angiotensin AT2 receptor antagonists reported to be useful for the treatment of neuropathy and neuropathic pain.

Neurology/psychiatric

PN-6047 overcomes unwanted side effects of conventional opioids

Dec. 20, 2024

The regular use of agonists of the μ-opioid receptor for acute pain relief usually leads to tolerance, respiratory depression, constipation and importantly, abuse potential.

Neurology/psychiatric

Sangamo’s ST-503 receives IND clearance for idiopathic small fiber neuropathy

Nov. 20, 2024

Sangamo Therapeutics Inc. has received IND clearance from the FDA for ST-503, an investigational epigenetic regulator for the treatment of intractable pain due to idiopathic small fiber neuropathy (iSFN).

Neurology/psychiatric

Humanwell Healthcare describes new angiotensin AT2 receptor antagonists

Oct. 23, 2024

Humanwell Healthcare (Group) Co. Ltd. has patented compounds acting a type-2 angiotensin II receptor (AGTR2; AT2) antagonists reported to be useful for the treatment of neuropathy and neuropathic pain.

Man holding raised arm with illustrated overlay of nerves

Inflammatory

COX-2 inhibitor AAT-076 ameliorates neuropathic pain

Aug. 12, 2024

AAT-076 was tested in the preclinical setting for its analgesic potential in COX-1 and COX-2 assays, as well as in in vivo rat models of air pouch inflammation, adjuvant-induced arthritis and neuropathic pain models. The compound was selected as a candidate analgesic compound due to its effective COX-2 inhibition within the central nervous system.

Neurology/psychiatric

PIPE-791 is antinociceptive in peripheral neuropathy model

Aug. 9, 2024

Researchers from Contineum Therapeutics Inc. have presented preclinical data for the novel brain penetrant lysophosphatidic acid receptor 1 (LPAR1) antagonist, PIPE-791, being evaluated in models of neuropathic pain.

Neurology/psychiatric

University of Copenhagen discovers new PSD-95 inhibitors for neuropathic pain

July 16, 2024

University of Copenhagen has described cyclic peptides acting as postsynaptic density-95 (PSD-95) protein inhibitors reported to be useful for the treatment of neuropathic pain.

Neurology/Psychiatric

Pannex Therapeutics presents new PANX1 inhibitors

March 25, 2024

Pannex Therapeutics Inc. has divulged pannexin-1 (PANX1; MRS1) inhibitors reported to be useful for the treatment of neuropathic pain and opioid dependency.

Neurology/Psychiatric

TMEM97 as a new therapeutic target for the treatment of neuropathic pain

Jan. 16, 2024

The σ2 receptor (σ2R) has been recently identified as transmembrane protein 97 (TMEM97), and ligands of σ2R/TMEM97 have previously shown the ability to alleviate mechanical hypersensitivity in mouse models of neuropathic pain.

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