Investigators at KU Leuven have discovered that although mTOR signaling was important in primary breast tumors and lung metastases alike, the signals that activated mTOR were different between the two, and mTOR signaling could be inhibited through different mechanisms.

Ketamine's antidepressant actions depend on the drug's ability to affect mRNA translation, researchers reported in the December 17, 2020, issue of Nature.

Lowering levels of tau protein improved multiple symptoms of autism spectrum disorders (ASD) in two different mouse models of the disease, both of which are driven by hyperactivity of the mTOR PI3 kinase pathway.

Lowering levels of tau protein improved multiple symptoms of autism spectrum disorders (ASD) in two different mouse models of the disease, both of which are driven by hyperactivity of the mTOR PI3 kinase pathway.