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BioWorld - Sunday, February 8, 2026
Home » circular RNA

Articles Tagged with ''circular RNA''

Liver illustration
Gastrointestinal

First circRNA-based protein replacement therapy for liver fibrosis

Jan. 19, 2026
No Comments
Researchers from Shanghai Institute of Nutrition and Health and Guangming Advanced Research Institute (China) proposed a new strategy based on a circular RNA (circRNA) encoding human relaxin-2 (cRLN2). circRNAs, thanks to their high stability and low immunogenicity, have been proposed as promising new drugs for several applications.
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Rznomics logo

Rznomics drives $31M Kosdaq IPO for RNA gene therapies

Dec. 23, 2025
By Marian (YoonJee) Chu
No Comments
Rznomics Inc. continued South Korea’s year-end biotech rally with a ₩46.35 billion (US$31.35 million) IPO Dec. 18. Proceeds will fund Seongnam-si, South Korea-based Rznomic’s pipeline of gene therapies, built on the company’s trans-splicing ribozyme RNA Replacement Enzyme technology platform.
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Rznomics logo

Rznomics drives $31M Kosdaq IPO for RNA gene therapies

Dec. 18, 2025
By Marian (YoonJee) Chu
No Comments
Rznomics Inc. continued South Korea’s year-end biotech rally with a ₩46.35 billion (US$31.35 million) IPO Dec. 18. Proceeds will fund Seongnam-si, South Korea-based Rznomic’s pipeline of gene therapies, built on the company’s trans-splicing ribozyme RNA Replacement Enzyme technology platform.
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Circode executives
Newco news

Circode applies circRNA to heart disease drug R&D, in vivo CAR T

July 15, 2025
By Marian (YoonJee) Chu
No Comments
Shanghai Circode Biomed Co. Ltd. is set to begin clinical trials of HM-2002, a circular RNA (circRNA)-based drug for ischemic heart disease, having gained IND clearance in China Jan. 10 and the U.S. on May 30, Circode CEO Chenxiang Tang recently told BioWorld.
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Circode executives
Newco news

Circode applies circRNA to heart disease drug R&D, in vivo CAR T

July 11, 2025
By Marian (YoonJee) Chu
No Comments
Shanghai Circode Biomed Co. Ltd. is set to begin clinical trials of HM-2002, a circular RNA (circRNA)-based drug for ischemic heart disease, having gained IND clearance in China Jan. 10 and the U.S. on May 30, Circode CEO Chenxiang Tang recently told BioWorld.
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Colorful illustration of the heart
Cardiovascular

Circode Biomed’s HM-2002 gains US IND clearance for ischemic heart disease

June 2, 2025
No Comments
Shanghai Circode Biomed Co. Ltd. has obtained IND clearance from the FDA for HM-2002 for ischemic heart disease. It previously received IND clearance in China in January this year.
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Molecules and RNA enclosed by a lipid bilayer
Hematologic

Orna, Vertex next-gen sickle cell, thalassemia deal could reach $4.3B+

Jan. 8, 2025
By Karen Carey
About four years after launch, Orna Therapeutics Inc. signed its second major deal, this time validating the lipid nanoparticle delivery technology it acquired through its Renagade Therapeutics Inc. buyout in May 2024, with Vertex Pharmaceuticals Inc. seeking next-generation approaches for hemoglobinopathies.
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Molecules and RNA enclosed by a lipid bilayer

Orna, Vertex next-gen sickle cell, thalassemia deal could reach $4.3B+

Jan. 7, 2025
By Karen Carey
About four years after launch, Orna Therapeutics Inc. signed its second major deal, this time validating the lipid nanoparticle delivery technology it acquired through its Renagade Therapeutics Inc. buyout in May 2024, with Vertex Pharmaceuticals Inc. seeking next-generation approaches for hemoglobinopathies.
Read More
Nanoparticle illustration
Drug design, drug delivery & technologies

Altamira Therapeutics achieves nanoparticle-based delivery of circular mRNA

Jan. 2, 2025
Altamira Therapeutics Ltd.’s nanoparticle-based delivery platform has been successfully tested for circular mRNA.
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RNA strand
Ear, nose & throat

Ribox’s RXRG-001 cleared to enter clinic for radiation-induced xerostomia and hyposalivation

Oct. 28, 2024
Ribox Therapeutics Ltd. has obtained IND clearance from the FDA for the company’s circular RNA therapy, RXRG-001.
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