North Carolina State University has synthesized vancomycin derivatives containing a 2,3-pyrrolidinedione moiety and reported to be useful for the treatment of bacterial infections.
The development of new antimicrobials to combat bacterial resistance is an urgent need given the increasing presence of multidrug-resistant organisms, an important concern especially for vulnerable individuals.
Researchers at F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have disclosed zwitterionic compounds reported to be useful for the treatment of bacterial infections.
By sequencing the bacterial mRNA that bacteria break down (the degradome) during protein synthesis, a novel approach called 5PSeq was able to analyze how environmental exposure stress, including that of antibiotics, affected bacterial translational dynamics. This is what researchers from the Karolinska Institutet led by Vicent Pelechano have discovered in their study published on May 22, 2023, in Nature Microbiology.
The Memed BV test, developed by Memed Diagnostics Ltd. to distinguish between bacterial and viral infections, offers an accurate diagnosis of the infection in children, and reduces the unnecessary prescription of antibiotics by physicians, according to a study published in the journal, PLOS One.
Bugworks Research India Pvt. Ltd. has identified oxazolidinone compounds acting as DNA gyrase and DNA topoisomerase IV (Escherichia coli) inhibitors reported to be useful for the treatment of bacterial infections, in particular gram-positive and gram-negative, as well as viral, fungal and protozoal infections.
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have divulged imidazole derivatives reported to be useful for the treatment of bacterial infections.
