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BioWorld - Saturday, April 4, 2026
Home » Madrigal Pharmaceuticals Inc.

Articles Tagged with ''Madrigal Pharmaceuticals Inc.''

Arrows pointing upward
Biopharma deals February 2026

Biopharma deal value jumps 60% to start 2026

March 17, 2026
By Amanda Lanier
No Comments
Biopharma deal value reached $61.17 billion in the first two months of 2026, roughly a 60% increase from the $38.11 billion logged in the same period of 2025 and marking the strongest early year total in BioWorld’s records. The surge was driven by unusually strong activity in both months, with $31.16 billion in January and $30.01 billion in February.
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Arrows pointing upward
Biopharma deals February 2026

Biopharma deal value jumps 60% to start 2026

March 13, 2026
By Amanda Lanier
No Comments
Biopharma deal value reached $61.17 billion in the first two months of 2026, roughly a 60% increase from the $38.11 billion logged in the same period of 2025 and marking the strongest early year total in BioWorld’s records. The surge was driven by unusually strong activity in both months, with $31.16 billion in January and $30.01 billion in February.
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Madrigal adds siRNA approach to MASH pipeline in $4.4B Ribo deal

Feb. 24, 2026
No Comments
Continuing to build on the successful launch of Rezdiffra (resmetirom), Madrigal Pharmaceuticals Inc. is adding six preclinical-stage siRNA therapies to its metabolic dysfunction-associated steatohepatitis (MASH) pipeline in a deal with Ribo Life Science Co. Ltd. and its subsidiary, Ribocure Pharmaceuticals AB, that could be worth $4.4 billion if all milestones are achieved.
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Madrigal adds siRNA approach to MASH pipeline in $4.4B Ribo deal

Feb. 11, 2026
No Comments
Continuing to build on the successful launch of Rezdiffra (resmetirom), Madrigal Pharmaceuticals Inc. is adding six preclinical-stage siRNA therapies to its metabolic dysfunction-associated steatohepatitis (MASH) pipeline in a deal with Ribo Life Science Co. Ltd. and its subsidiary, Ribocure Pharmaceuticals AB, that could be worth $4.4 billion if all milestones are achieved.
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siRNA bound to mRNA
Gastrointestinal

Madrigal licenses six Ribo siRNA programs

Feb. 11, 2026
No Comments
Madrigal Pharmaceuticals Inc. has signed an exclusive global license agreement with Suzhou Ribo Life Science Co. Ltd. and its subsidiary Ribocure Pharmaceuticals AB for six preclinical small interfering RNA (siRNA) programs.
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Novo’s Wegovy swings into monster MASH space

Aug. 18, 2025
By Randy Osborne
No Comments

With the U.S. FDA clearance of the sNDA for Wegovy (semaglutide) from Novo Nordisk A/S to treat noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH), Wall Street speculation deepened as to the consequences for Madrigal Pharmaceuticals Inc.’s Rezdiffra (resmetirom), a thyroid hormone receptor-beta (THR-beta) agonist that won the MASH go-ahead last year.


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Rezdiffra
Endocrine/metabolic

GLP-1, Rezdiffra MASH-up eyed in $2B Madrigal/CSPC deal

Aug. 5, 2025
By Randy Osborne
No Comments
Madrigal Pharmaceuticals Inc.’s long-awaited business development pact became reality by way of an exclusive global license agreement that could be worth more than $2 billion with CSPC Pharmaceutical Group Ltd., of Shijiazhuang, China, for SYH-2086. The candidate is a preclinical oral, small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist and orforglipron derivative.
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Rezdiffra
Endocrine/metabolic

GLP-1, Rezdiffra MASH-up eyed in $2B Madrigal/CSPC deal

Aug. 1, 2025
By Randy Osborne
No Comments
Madrigal Pharmaceuticals Inc.’s long-awaited business development pact became reality by way of an exclusive global license agreement that could be worth more than $2 billion with CSPC Pharmaceutical Group Ltd., of Shijiazhuang, China, for SYH-2086. The candidate is a preclinical oral, small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist and orforglipron derivative.
Read More
Rezdiffra

GLP-1, Rezdiffra MASH-up eyed in $2B Madrigal/CSPC deal

July 30, 2025
By Randy Osborne
No Comments
Madrigal Pharmaceuticals Inc.’s long-awaited business development pact became reality by way of an exclusive global license agreement that could be worth more than $2 billion with CSPC Pharmaceutical Group Ltd., of Shijiazhuang, China, for SYH-2086. The candidate is a preclinical oral, small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist and orforglipron derivative.
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Liver disease
Endocrine/metabolic

Madrigal obtains rights to CSPC Pharmaceutical’s SYH-2086

July 30, 2025
No Comments
Madrigal Pharmaceuticals Inc. and CSPC Pharmaceutical Group Ltd. have entered into an exclusive global license agreement for CSPC’s SYH-2086, a preclinical oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist and orforglipron derivative. The agreement supports Madrigal’s pipeline strategy to develop combination treatments for metabolic dysfunction-associated steatohepatitis (MASH).
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