Keeping you up to date on recent developments in oncology, including: MR touted as potential screening modality for prostate cancer; Classifying variants of unknown significance; Tumor neoantigens can inhibit immune response; MEK perhaps a useful target in some bladder cancers.
PERTH, Australia – The fight against diffuse intrinsic pontine glioma may finally see some progress, after experiments using 3D models of the tumor in animal studies showed that a combination therapy of the polyamine inhibitor AMXT-1501 (Aminex Therapeutics Inc.) and the ornithine decarboxylase 1 inhibitor difluoromethylornithine could eradicate cancer cells.
A study of the epigenetic enzyme Pr-set7/Set8 by researchers at Duke-NUS Medical School in Singapore has shown it to play a key role in stimulating neural stem cells (NSCs) from their quiescent state, enabling their proliferation and the generation of new neurons.
Organoids grown from cholangiocytes – the epithelial cells of the bile duct – are poised to be used in ex vivo cell therapy to increase the number of donated livers that are suitable for transplant, and also for direct bile duct repairs. The organoids have been shown to be effective in correcting defects in mouse models and in perfused donated livers. They are now being tested in large animal models.
Keeping you up to date on recent developments in cardiology, including: Algorithm can make echocardiography a breeze for the inexperienced; Algorithm suppresses CT scan time in chest imaging studies; Study shows distal radial access better for occlusion.
Keeping you up to date on recent developments in neurology, including: Deep brain stimulation prevents epileptic seizures in mouse model; Researchers discover promising biomarkers to diagnose mild TBI; New information on how antidepressants affect the brain uncovered.
BioWorld looks at translational medicine, including: Classifying variants of unknown significance; Platelets release antigenic DNA in lupus; Intracranial samples give glimpse into stroke response.
Researchers at the University of California San Diego (UCSD) have taken wearables to a new level with a soft skin patch that integrates functions currently siloed in continuous glucose monitors, wearables, wellness apps and hospital monitors. The all-in-one patch can be worn on the neck to continuously track blood pressure, heart rate, glucose, lactate, alcohol and caffeine.
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