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DNA sequencing

Passengers, noncoding genome affect how cancers play out

Feb. 20, 2020
By Anette Breindl
Beyond every binary is a more complex reality. And so it is with driver and passenger mutations. The separation of tumor mutations into drivers and passengers underpins much progress in the development of targeted therapies. By looking at passenger mutations more carefully, though, researchers at Yale University have shown that passenger mutations, too, played a role in how tumors progressed.
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BioWorld MedTech’s Orthopedics Extra for Feb. 19, 2020

Feb. 19, 2020
By Holland Johnson
Keeping you up to date on recent developments in orthopedics, including: In2bones reports U.S. Launch of the Avenger radial head prosthesis; Searching for biomarkers and therapeutic agents against breast cancer; MRI findings predict shoulder stiffness for rotator cuff tears.
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Progression of alpha-synuclein pathology
The lysosome link

Strengthening lysosomes could head Parkinson’s off at the pass

Feb. 19, 2020
By Anette Breindl
Parkinson’s disease (PD) is a neurodegenerative disorder. But not just. And it may not start that way. There is increasing evidence that a-synuclein, the protein whose aggregates eventually destroy midbrain dopaminergic neurons in PD (and that are the cause of other diseases collectively known as the synucleinopathies), first aggregates “in enteric neurons, the neurons that control gastrointestinal function,” Collin Challis told BioWorld.
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Cells, DNA illustration

AAAS 2020: Progress in Human Cell Atlas unveiling underlying mechanisms of disease

Feb. 19, 2020
By Nuala Moran
SEATTLE – As it enters its third year, the Human Cell Atlas project has mapped 100 million of 100 billion cells, and by comparing gene expression profiles of normal and aberrant cells and building networks of cellular interactions, is leading to breakthroughs in understanding of disease at a molecular level.
Read More
Coronavirus and DNA
American Association for the Advancement of Science

Researchers trace COVID-19’s family tree to battle outbreak and ‘infodemic’

Feb. 18, 2020
By Nuala Moran
SEATTLE – Tracing the family tree of COVID-19 through its evolving DNA sequence makes it possible to disprove many false claims circulating on social media about the novel coronavirus, and, in particular, that it was generated in a covert biological weapons program. “From everything I’ve looked at, there is zero evidence for genetic engineering; it looks like normal evolution,” said Trevor Bedford, a computational biologist at Fred Hutchinson Cancer Research Center, who has been using genomes sequences taken from patient samples to track the spread of the virus since Jan. 11.
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BioWorld MedTech’s Oncology Extra for Feb. 18, 2020

Feb. 18, 2020
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology, including: New approach to photothermal treatment beats biofilm problem; Origin story helps ovarian cancer prognosis; Sharper look yields new potential kinase target in ovarian cancer; Autophagy activation may prevent metastasis.
Read More
Cells, DNA illustration

AAAS 2020: Progress in Human Cell Atlas unveiling underlying mechanisms of disease

Feb. 18, 2020
By Nuala Moran
SEATTLE – As it enters its third year, the Human Cell Atlas project has mapped 100 million of 100 billion cells, and by comparing gene expression profiles of normal and aberrant cells and building networks of cellular interactions, is leading to breakthroughs in understanding of disease at a molecular level.
Read More
Coronavirus and DNA
American Association for the Advancement of Science

Researchers trace COVID-19’s family tree to battle outbreak and ‘infodemic’

Feb. 18, 2020
By Nuala Moran
SEATTLE – Tracing the family tree of COVID-19 through its evolving DNA sequence makes it possible to disprove many false claims circulating on social media about the novel coronavirus, and, in particular, that it was generated in a covert biological weapons program.
Read More
Coronavirus and DNA
American Association for the Advancement of Science

Researchers trace COVID-19’s family tree to battle outbreak and ‘infodemic’

Feb. 14, 2020
By Nuala Moran
SEATTLE – Tracing the family tree of COVID-19 through its evolving DNA sequence makes it possible to disprove many false claims circulating on social media about the novel coronavirus, and, in particular, that it was generated in a covert biological weapons program. “From everything I’ve looked at, there is zero evidence for genetic engineering; it looks like normal evolution,” said Trevor Bedford, a computational biologist at Fred Hutchinson Cancer Research Center, who has been using genomes sequences taken from patient samples to track the spread of the virus since Jan. 11.
Read More

BioWorld MedTech’s Neurology Extra for Feb. 14, 2020

Feb. 14, 2020
By Andrea Applegate
Keeping you up to date on recent developments in neurology, including: PTSD linked to a dysfunction of the brain networks that control memory; Molecule offers hope for halting Parkinson's; Brain abnormalities associated with schizophrenia in individuals with 22q revealed.
Read More
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