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BioWorld - Saturday, June 10, 2023
Home » Topics » Science

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Pancreatic desmoplasia
Cancer

AACR 2023: Thinking of heterogeneities as multiple shots on goal

April 17, 2023
By Anette Breindl
No Comments
Heterogeneity, in both tumors and their microenvironment, limits the success of current cancer treatments. But it also provides opportunities. Heterogeneities “are not barriers to therapy, they are vulnerabilities to be exploited,” was how David DeNardo described his take at the 2023 annual meeting of the American Association for Cancer Research (AACR) on Sunday.
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Gene editing illustration

Base editing rescues spinal muscular atrophy in vivo

April 10, 2023
By Mar de Miguel
No Comments
The editing in human cells and in mice of the survival motor neuron 1 gene (SMN1) restored the levels of SMN protein that the mutation of the SMN2 gene produces in spinal muscular atrophy. Scientists from the Broad Institute in Boston and The Ohio State University reversed the mutation using the base editing technique.
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Illustration showing the different types of vaccines that are tested against coronavirus
Infection

Live-attenuated nasal vaccine shows early promise against COVID-19

April 6, 2023
By Helen Albert
No Comments
A live-attenuated vaccine targeting SARS-CoV-2 infection, which can be administered through the nose, has shown promise in preclinical animal studies carried out by researchers in Berlin. In an article published April 3, 2023, in Nature Microbiology, the authors reported that the COVID-19 vaccine candidate – sCPD9 – triggered the most robust immune response in a hamster model when compared with Biontech/Pfizer’s mRNA vaccine BNT162b2 and Ad2-Spike.
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Illustration of leg anatomy with target around knee
Inflammatory

Partially blocking inflammatory receptor could lead to treatment for osteoarthritis

March 24, 2023
By Helen Albert
No Comments
Partially blocking a receptor that helps regulate the activity of the inflammatory cytokine molecule interleukin-6 (IL-6) seems to promote tissue regeneration and block degeneration in a model of osteoarthritis. As reported in the March 22, 2023, issue of Science Translational Medicine, the receptor, called glycoprotein 130 (gp130), regulates both positive and negative inflammatory responses that can help regenerate tissue, but also cause degeneration.
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Concept art for Mitochondrial DNA.
Inflammatory

Fumarate accumulation moderates inflammation through mitochondrial genetic material

March 10, 2023
By Mar de Miguel
No Comments
A deficiency in fumarate metabolism could be behind a new mechanism of inflammation mediated by mitochondrial DNA and RNA. Two independent and simultaneous studies described how the accumulation of fumarate in the mitochondria released the genetic material of this organelle through vesicles, activating an inflammatory signaling pathway.
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DNA repair
International Summit on Human Genome Editing

Somatic genome editing pricey, germline editing still risky, researchers conclude

March 9, 2023
By Nuala Moran
No Comments
Somatic human genome editing has made huge strides in the past five years, but the likely extremely high prices will be unsustainable. A global commitment to affordable, equitable access is urgently needed because the costs and infrastructure needs of this form of treatment are not manageable for either patients or health care systems.
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DNA, fetus illustration
International Human Genome Editing Conference

Prenatal gene-editing treatment offers curative potential for serious inherited disease

March 8, 2023
By Nuala Moran
No Comments
The researcher who pioneered prenatal surgery to correct neural tube defects has turned her attention to using CRISPR-edited gene therapies to correct severe monogenic diseases in utero. The availability of prenatal genetic diagnosis and advances in treating fetuses, and also in gene therapy/gene editing, make it possible to repair almost any defect in the genetic code. At the same time, there is a clear rationale for intervening before birth, Tippi MacKenzie, professor of surgery at UCSF’s School of Medicine, told attendees of the third International Human Genome Editing Conference in London on March 7.
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Biocom space-panel

Biocom 2023: There’s science going on 250 miles above your head

March 7, 2023
By Brian Orelli
No Comments
Performing experiments and potentially manufacturing products in space offers some unique advantages in a near-zero gravity environment. Space changes buoyancy, hydrostatic pressure and convective heat flow. Researchers are studying how those changes affect cells, but also looking to take advantage of the changes to create products in manufacturing processes that wouldn’t be possible on earth.
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Illustration of brain in head highlighting the blood-brain barier.
Cancer

ESMO TAT: Tumor therapies find new ways into the brain, by finesse or force

March 7, 2023
By Anette Breindl
No Comments
Whether as primary tumors or metastases, brain tumors remain stubbornly intractable to the progress that has occurred in many other tumor types. As Igor Vivanco, who is a senior lecturer in the Institute of Pharmaceutical Science at King’s College London, noted in his talk at the European Society for Medical Oncology Targeted Anticancer Therapies (ESMO TAT) meeting in Paris this week, the last win in glioblastoma was the addition of temozolomide to the radiotherapy standard of care in 2005. And temozolomide’s benefit is measured in months, not years.
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Biocom space-panel

Biocom 2023: There’s science going on 250 miles above your head

March 1, 2023
By Brian Orelli
No Comments
Performing experiments and potentially manufacturing products in space offers some unique advantages in a near-zero gravity environment. Space changes buoyancy, hydrostatic pressure and convective heat flow. Researchers are studying how those changes affect cells, but also looking to take advantage of the changes to create products in manufacturing processes that wouldn’t be possible on earth.
Read More
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