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BioWorld - Thursday, August 11, 2022
Home » Topics » Science

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3D model of a protein molecule

‘3D view of the protein universe’ as Deepmind reveals 200M protein structures

July 29, 2022
By Nuala Moran
No Comments
It is now possible to look up the 3D structure of every known protein following the latest release of Alphafold, an open database run in partnership by Deepmind, the London-based artificial intelligence company owned by Google parent Alphabet and the European Molecular Biology Laboratory’s European Bioinformatics Institute in Cambridge, U.K.
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Professor Hugh Watkins, lead investigator at Cureheart

Scientists to test whether base editing could cure killer heart diseases

July 29, 2022
By Richard Staines
No Comments
Scientists will investigate whether cutting-edge technology such as base editing could be used to cure inherited heart muscle conditions after an international team co-led by Harvard Medical School won a research challenge. The $36 million Big Beat Challenge, run by the British Heart Foundation, is one of the largest non-commercial awards ever given and will focus on inherited heart muscle diseases known as genetic cardiomyopathies.
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Person holding stomach in pain

Gut bug-produced histamine worsens abdominal pain in irritable bowel syndrome

July 29, 2022
By Mar de Miguel
No Comments
According to a new study published in the July 27, 2022, issue of Science Translational Medicine, a lower intake of fermentable carbohydrates produces changes in the intestinal microbiota that decrease histamine production reducing chronic abdominal pain in patients with irritable bowel syndrome.
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Coronavirus spike protein

Targeting S2 could lead to broad coronavirus protection

July 29, 2022
By Nuala Moran
No Comments
Since the very beginning of the COVID-19 pandemic, in addition to the attempts to rapidly develop a vaccine that was effective against current strains, researchers have been looking for a vaccine that could protect more broadly against multiple coronaviruses. That has prompted attempts to harness the potential of the more conserved S2 subunit of the spike protein via which SARS-CoV-2 enters human host cells.
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Brain cancer illustration

Neuron-like cells are glioblastoma's evil mastermind

July 28, 2022
By Anette Breindl
No Comments
Tumor heterogeneity is recognized as an important way in which tumors are able to grow, invade surrounding tissue, metastasize and develop resistance to therapies. But linking specific states to the overall biology of tumors has been a challenge.
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Map illustrating origin and spread of coronavirus

New analyses conclude that lab origin of SARS-CoV-2 is ‘extremely unlikely’

July 27, 2022
By Nuala Moran
No Comments
The controversy about the origins of the SARS-CoV-2 virus and the accusations that it escaped from the Wuhan Institute of Virology, or even that it was deliberately engineered there, could – possibly – be brought to a close by two papers published July 26, 2022.
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Antibodies attacking cancer cell

Monoclonal antibody pairs "zipper" to target cancer

July 27, 2022
By Mar de Miguel
No Comments
Two targets, double success. This is the logic behind a new approach that uses monoclonal antibody pairs to fight cancer.
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Microscope

Nonessential but critical, tyrosine plays key role in nutrient sensing

July 26, 2022
By Anette Breindl
No Comments
Investigators at the Riken Institute have demonstrated that while tyrosine is a nonessential amino acid, meaning that it can be synthesized by the body and does not need to be taken up in the diet, it has an essential function as far as nutrient sensing is concerned.
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Novel coronavirus SARS-CoV-2

SARS-CoV-2 infection of neurons; no ACE2 required

July 22, 2022
By Mar de Miguel
No Comments
Since the isolation of SARS-CoV-2 and the study of its infection mechanisms, scientists have been trying to understand how this virus accesses the brain and produces neurological symptoms. The receptor necessary for the virus to enter the cell by endocytosis (the receptor for angiotensin-converting enzyme 2, ACE2) is only expressed by some neurons and is hardly detected in the brain.
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Cancer cells

Oncogenic collagen allows cancer cells to evade immune response

July 22, 2022
By Mar de Miguel
No Comments
Cancer cells may evade the immune response thanks to a special type of collagen, scientists reported in a new study published in the July 21, 2022, issue of Cancer Cell. Researchers at The University of Texas MD Anderson Cancer Center have discovered oncogenic collagen secreted by cancer cells that differs from normal collagen.
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