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BioWorld - Friday, June 6, 2025
Home » Topics » Science

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3D illustration of melanoma
Cancer

Combination therapy overcomes treatment resistance in melanoma

March 4, 2025
By Mar de Miguel
Researchers at the University of California San Diego have uncovered a key mechanism underlying the treatment resistance of melanoma with the BRAF V600E mutation through pathways involved in focal adhesion and extracellular matrix (ECM) remodeling. These two processes remodel the tumor cell environment in melanoma through the RAF/MEK cell signaling pathway. However, the combined use of FAK inhibitors with a RAF-MEK clamp overcame this resistance.
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AI-generated depiction of lungs affected by cystic fibrosis
Respiratory

‘Remarkable’ progress in cystic fibrosis means more work needed

Feb. 28, 2025
By Nuala Moran
The map of cystic fibrosis (CF) research is being redrawn in the U.K. as improvements in treatment, and in particular the introduction of CF modulator drugs, mean people with the rare inherited disease are living much longer.
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Mitochondria
Genetic/congenital

For therapeutic hypoxia, small molecule can mimic mountain trip

Feb. 28, 2025
By Anette Breindl
Too much of a good thing, it turns out, is a concept that applies to oxygen. And researchers at the University of California at San Francisco are working on a small molecule, Hypoxystat, that can lower tissue oxygen levels and prevent damage when oxygen levels are too high. When administered to mice with the rare mitochondrial disorder Leigh syndrome, the molecule more than tripled their average lifespan.
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AI-generated depiction of lungs affected by cystic fibrosis

‘Remarkable’ progress in cystic fibrosis means more work needed

Feb. 27, 2025
By Nuala Moran
The map of cystic fibrosis (CF) research is being redrawn in the U.K. as improvements in treatment, and in particular the introduction of CF modulator drugs, mean people with the rare inherited disease are living much longer.
Read More
Cancer cells under magnifying glass
Cancer

Insights into extracellular matrix are metastasis map

Feb. 24, 2025
By Nuala Moran
New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses of cancer cells, showing how they alter their gene expression to ‘escape’ from ECM.
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Electron microscopy of E. coli bacteria.
Genetic/congenital

Eliminating redundancies opens up possibilities for protein engineering

Feb. 24, 2025
By Anette Breindl
Researchers have altered the genetic code in a strain of Escherichia coli, reducing the number of stop codons from three to one and assigning the freed-up stop codons to nonstandard amino acids. They reported on the recoded bacterium, which they named OCHRE, in Nature on Feb. 5, 2025.
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Small extracellular vesicle

Clots and metastasis in cancer patients start in the lung

Feb. 21, 2025
By Mar de Miguel
The lung and thrombosis may play a key role in cancer and metastasis progression, according to a collaborative study led by Cornell University scientists.
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Lung cancer illustration
Cancer

GUK1 is metabolic gate in ALK-driven lung cancer

Feb. 21, 2025
By Xavier Bofill Bruna
Using ALK+ lung cancer patient-derived cell lines, researchers have performed phosphoproteomic screening and identified guanylate kinase 1 (GUK1) as a TKI sensitive metabolic molecule in ALK-driven lung cancer.
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US flag with microscope

Trump administration an existential threat to science, warns AAAS chief

Feb. 19, 2025
By Nuala Moran
The scientific establishment has launched a fight back against the Trump administration and the slew of executive orders that threaten to dismantle research funding, with a warning that the next month could be critical for the future of U.S. science.
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Lung cancer illustration
Cancer

GUK1 is metabolic gate in ALK-driven lung cancer

Feb. 19, 2025
By Xavier Bofill Bruna
Using ALK+ lung cancer patient-derived cell lines, researchers have performed phosphoproteomic screening and identified guanylate kinase 1 (GUK1) as a TKI sensitive metabolic molecule in ALK-driven lung cancer. They reported their results online in Cell on Feb. 6, 2025.
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