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Illustration of human brain and dna
Neurology/psychiatric

Commander proteins linked to lysosomal dysfunction in Parkinson’s

April 22, 2025
By Mar de Miguel
Genes associated with lysosomal dysfunction increase the risk of Parkinson’s disease (PD), according to a study led by scientists at Northwestern University. The discovery also explains why some people who carry a pathogenic variant of the GBA1 gene develop PD or dementia with Lewy bodies (DLB) and others do not. The key lies in the Commander complex, involved in the transport of proteins to this organelle. This discovery raises the need for combinatorial therapies that act on more than one pathway for this type of neurodegenerative disorder.
Read More
DNA double helix with sand hour glass

M42 enters R&D with investment in longevity firm Juvenescence

April 16, 2025
By Nuala Moran
The Abu Dhabi health care company M42 is to make an investment in U.K.-based longevity specialist Juvenescence as a route to moving into drug discovery and development, with the two forming a partnership to work together on products that extend the healthy lifespan and improve the treatment of chronic diseases.
Read More
Concept art for stem cell implantation

Stem cell therapies show safety in clinical trials in Parkinson's

April 16, 2025
By Mar de Miguel
Stem cell implantation is a step closer to becoming the next strategy against Parkinson's disease. Two clinical trials, one in phase I and the other in phase I/II, have demonstrated their safety and potential to restore dopamine production in the brains of patients with this currently incurable neurodegenerative condition. The number of participants in the study is still small, and further research is needed to demonstrate the clinical benefits of these cell therapies.
Read More
Illustration of human brain and dna
Neurology/psychiatric

Commander proteins linked to lysosomal dysfunction in Parkinson’s

April 16, 2025
By Mar de Miguel
Genes associated with lysosomal dysfunction increase the risk of Parkinson’s disease (PD), according to a study led by scientists at Northwestern University. The discovery also explains why some people who carry a pathogenic variant of the GBA1 gene develop PD or dementia with Lewy bodies (DLB) and others do not. The key lies in the Commander complex, involved in the transport of proteins to this organelle. This discovery raises the need for combinatorial therapies that act on more than one pathway for this type of neurodegenerative disorder.
Read More
Antibodies binding to spike proteins on the surface of SARS-CoV-2 virus
Inflammatory

Australian researchers discover new compound to treat long COVID

April 15, 2025
By Tamra Sami
Researchers have developed a new compound that can prevent long COVID symptoms in mice that could lead to a future drug for the debilitating condition in humans. Developed by researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, the world-first study found mice treated with the antiviral compound were protected from long-term brain and lung dysfunction, which are key symptoms of long COVID.
Read More
Viruses

Pandemic potential is plentiful, but the next bug’s specifics are known unknown

April 15, 2025
By Anette Breindl
Compared to other forms of prevention, a unique issue for pandemic preparedness is that it is forever unclear what pathogen, exactly, the world needs to be prepared for. There are an estimated 300,000 viruses that infect mammals; add in birds, and the estimate grows to more than half a million. Some of those viruses are much greater threats than others.
Read More
Antibodies binding to spike proteins on the surface of SARS-CoV-2 virus
Inflammatory

Australian researchers discover new compound to treat long COVID

April 15, 2025
By Tamra Sami
Researchers have developed a new compound that can prevent long COVID symptoms in mice that could lead to a future drug for the debilitating condition in humans. Developed by researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, the world-first study found mice treated with the antiviral compound were protected from long-term brain and lung dysfunction, which are key symptoms of long COVID.
Read More
Art concept for gene therapy research
Genetic/congenital

Pretzel Therapeutics narrows the therapeutic gap for PolG disease

April 15, 2025
By Xavier Bofill Bruna
Researchers from Pretzel Therapeutics Inc. and the University of Gothenburg have published new insights on how mutations in the POLG gene affect its functionality and are tied to PolG diseases. They have also presented a compound for its potential treatment, PZL-A. They published their results in Nature on April 9, 2025.
Read More
Antibodies binding to spike proteins on the surface of SARS-CoV-2 virus
Inflammatory

Australian researchers discover new compound to treat long COVID

April 14, 2025
By Tamra Sami
Researchers have developed a new compound that can prevent long COVID symptoms in mice that could lead to a future drug for the debilitating condition in humans. Developed by researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, the world-first study found mice treated with the antiviral compound were protected from long-term brain and lung dysfunction, which are key symptoms of long COVID.
Read More
Colorful illustration of reconstructed brain cells
Neurology/psychiatric

Mouse brain structure and function shown on high-resolution map

April 11, 2025
By Mar de Miguel
Scientists from the Machine Intelligence from Cortical Networks (MICRONS) consortium have published the microconnectome of a cubic millimeter of the mouse brain. This is the most complete map of this organ to date at nanometer resolution for a mammal. It not only contains the structure and connections of each and every cell in that volume of tissue, but is also linked to the neuronal activity of that portion of the CNS, linking anatomy and function in the same cells.
Read More
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