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Kidneys

Targeting senescent cells restores kidney function

May 26, 2021
By W. Todd Penberthy
Researchers at the Center for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh reported in the May 19, 2021, issue of Science Translational Medicine that the Bcl2/w/xL targeting senolytic compound, ABT-263 (navitoclax) could reverse the age-related fibrosis characteristic of and improve kidney function.
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Close-up of eye

All eyes are on autism screening app for toddlers

May 25, 2021
By Annette Boyle
With the support of the NIH’s National Institute of Child Health and Human Development and the National Institute of Mental Health, researchers at Duke University’s Center for Autism and Brain Development have developed a mobile app that can quickly screen toddlers for autism spectrum disorder without the need for specialized skills.
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Stem cells

"Invisible" T cells bioengineered from human iPSCs

May 25, 2021
By John Fox
Japanese scientists led by Shin Kaneko, an associate professor in the Center for iPS Cell Research and Application at Kyoto University, have developed the first practical bioengineering strategy for generating a universal pluripotent stem cell.
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Brain and blood cells

ASGCT 2021: Engineering blood cells can treat brain diseases

May 21, 2021
By Anette Breindl
Collectively, lysosomal storage disorders (LSDs) are caused by malfunctions in metabolic enzymes in the lysosome system. Depending on which enzyme is missing, toxic metabolites accumulate. While the LSDs are highly heterogenous – even within one disease, presentation can vary widely – neurodegeneration is a common feature in these disorders.
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Gloved hand holding petri dish in lab

Study identifies colistin resistance drug target

May 20, 2021
By John Fox
A Chinese study led by scientists at Zhejiang University in Hangzhou City has identified a linker of resistance from the mobile colistin resistance gene 3, which might represent a promising drug target against which to develop small-molecule inhibitors to reverse colistin resistance.
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Arthritis pain illustration

T-cell modulation elicits long-term arthritis remission

May 19, 2021
By John Fox
British and Taiwanese scientists have described a novel approach to the treatment of autoimmune rheumatoid arthritis, using an already approved DNA-methylation inhibitor, which was shown to effectively treat active inflammatory disease in animal models.
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Coronavirus, question marks
Origin stories

SARS-CoV-2 origin is hotly debated known unknown

May 18, 2021
By Anette Breindl
Roughly a year and a half after the start of the COVID-19 pandemic, many unknowns remain about the future of the virus. How it will mutate, how long protection from either illness or vaccination will last, when it will cease to be a pandemic and instead be endemic, even whether the worst is still ahead. And there is also an increasing acknowledgment that there remain unknowns about SARS-CoV-2’s past.
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Cancer cell, DNA illustration

Chromosomal fusion – an ALTernative tumor target for PARP inhibitors?

May 18, 2021
By Subhasree Nag
Investigators led by Russell Pieper at University of California, San Francisco have discovered that ALT-associated tumors are hypersensitive to a subgroup of poly [ADP-ribose] polymerase (PARP) inhibitors.
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Skeletal system

Australian researchers map out first genetic profile of skeletal master regulator cells

May 17, 2021
By Tamra Sami
Researchers at Australia's Garvan Institute of Medical Research have for the first time mapped the genetic profile of the skeleton's master regulator cells, known as osteocytes.
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Stomach, H. pylori

H. pylori oncoprotein-induced genome instability may underlie gastric cancer

May 14, 2021
By John Fox
A Japanese study has found that the Helicobacter pylori oncoprotein, CagA, elicited transient 'BRCAness', inducing genomic instability via DNA double-strand breaks and defective homologous recombination. The effects may underlie the gastric carcinogenesis associated with chronic H. pylori infection.
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