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BioWorld - Saturday, June 7, 2025
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Arthritis pain illustration

T-cell modulation elicits long-term arthritis remission

May 19, 2021
By John Fox
British and Taiwanese scientists have described a novel approach to the treatment of autoimmune rheumatoid arthritis, using an already approved DNA-methylation inhibitor, which was shown to effectively treat active inflammatory disease in animal models.
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Coronavirus, question marks
Origin stories

SARS-CoV-2 origin is hotly debated known unknown

May 18, 2021
By Anette Breindl
Roughly a year and a half after the start of the COVID-19 pandemic, many unknowns remain about the future of the virus. How it will mutate, how long protection from either illness or vaccination will last, when it will cease to be a pandemic and instead be endemic, even whether the worst is still ahead. And there is also an increasing acknowledgment that there remain unknowns about SARS-CoV-2’s past.
Read More
Cancer cell, DNA illustration

Chromosomal fusion – an ALTernative tumor target for PARP inhibitors?

May 18, 2021
By Subhasree Nag
Investigators led by Russell Pieper at University of California, San Francisco have discovered that ALT-associated tumors are hypersensitive to a subgroup of poly [ADP-ribose] polymerase (PARP) inhibitors.
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Skeletal system

Australian researchers map out first genetic profile of skeletal master regulator cells

May 17, 2021
By Tamra Sami
Researchers at Australia's Garvan Institute of Medical Research have for the first time mapped the genetic profile of the skeleton's master regulator cells, known as osteocytes.
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Stomach, H. pylori

H. pylori oncoprotein-induced genome instability may underlie gastric cancer

May 14, 2021
By John Fox
A Japanese study has found that the Helicobacter pylori oncoprotein, CagA, elicited transient 'BRCAness', inducing genomic instability via DNA double-strand breaks and defective homologous recombination. The effects may underlie the gastric carcinogenesis associated with chronic H. pylori infection.
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Illustration of mouse with chip implant

Columbia neuroelectronic system could improve epilepsy treatment and reduce side effects

May 13, 2021
By Annette Boyle
In the last decade, responsive neurostimulation (RNS) has become a mainstay of treatment for refractory focal epilepsy, but challenges with the technology remain. Researchers at Columbia University in New York appear to have overcome some of the major limitations through development of a compact, flexible, high performance implantable device that permits reading and manipulation of brain circuits.
Read More
Coronavirus, question marks
Origin stories

SARS-CoV-2 origin is hotly debated known unknown

May 13, 2021
By Anette Breindl
Roughly a year and a half after the start of the COVID-19 pandemic, many unknowns remain about the future of the virus. How it will mutate, how long protection from either illness or vaccination will last, when it will cease to be a pandemic and instead be endemic, even whether the worst is still ahead. And there is also an increasing acknowledgment that there remain unknowns about SARS-CoV-2’s past.
Read More
Brain and blood cells

ASGCT 2021: Engineering blood cells can treat brain diseases

May 13, 2021
By Anette Breindl
Collectively, lysosomal storage disorders (LSDs) are caused by malfunctions in metabolic enzymes in the lysosome system. Depending on which enzyme is missing, toxic metabolites accumulate. While the LSDs are highly heterogenous – even within one disease, presentation can vary widely – neurodegeneration is a common feature in these disorders.
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N. brasiliensis

AAI 2021: In immunity, IL-33 signals stop as well as go

May 12, 2021
By Anette Breindl
Parasitic worms, or helminths, are a major global health issue. At the same time, "parasites have been a prolific area of biomedical research to emerge," De'Broski Herbert told his audience at the 2021 annual meeting of the American Association of Immunologists.
Read More
DNA illustration

Findings bolster RAD51 as biomarker for DNA repair deficiency

May 11, 2021
By Anette Breindl
The discovery of synthetic lethality between BRCA mutations and PARP inhibitors ranks has led to major advances in the treatment of BRCA-mutated cancers. Mutations in BRCA1 and BRCA2 can leave cells with a deficiency in homologous repair (HR). And that deficiency can make them vulnerable to PARP inhibitors, which block alternate DNA repair pathways, as well as platinum-based treatment, which induces DNA mutations that BRCA-deficient cells are unable to cope with.
Read More
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