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Tape measure wrapped around feet on scale

Exome study identifies new genetic influences on weight

July 2, 2021
By Anette Breindl
An exome sequencing study of more than 600,000 individuals of European and mixed American ancestry has identified more than a dozen genes, including five brain-expressed G protein-coupled receptors, that were associated with body mass index.
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Immune macrophage
Use it to lose it

Fat-resident macrophages are metabolic decision-makers

July 1, 2021
By Anette Breindl
Researchers have identified an evolutionarily conserved metabolic role for tissue-resident macrophages, they reported in the July 2, 2021, issue of Science. In a commentary published alongside the paper, Conan O’Brien and Ana Domingos from the University of Oxford asserted that the work “introduces a new, macrophage-centered paradigm in… energy storage.”
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Stem cells

Back to the basics for new insights, with new technology

June 29, 2021
By Anette Breindl
Sometimes, scientific progress comes from conceptual insights that arrive in a flash. More often, however, such progress arrives in a decidedly less glamorous, though no less important, manner.
Read More
Tau neuron illustration

LDL receptor overexpression affects tauopathy in Alzheimer's model

June 29, 2021
By W. Todd Penberthy
Researchers report in the June 21, 2021, online issue of Neuron that overexpression of the LDL receptor can reduce ApoE to prevent tauopathy-associated neurodegeneration in mouse models.
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CD47 protein structure

ISSCR: Genome-edited stem cells can make immune-evading transplants

June 28, 2021
By Anette Breindl
Multiple companies are pursuing CD47-blockade as a tumor immunotherapy approach. Sana Biotechnology Inc., too, is interested in the therapeutic potential of CD47 – but from a very different angle. By overexpressing CD47 on stem cells, researchers at Sana want to make transplanted cells invisible to the immune system.
Read More
Neurons

Neurotrophic signaling deficiency exacerbates Alzheimer's risk factors

June 28, 2021
By John Fox
A deficiency in neurotrophic factor signaling has been shown to exacerbate environmental risk factors for the development of Alzheimer's disease pathogenesis in mice, according to a study reported in the June 22, 2021, online edition of the Proceedings of the National Academy of Sciences.
Read More
Tiny 3D-printed bioscaffold on gloved finger

Australian researchers outsmart 3D printers by printing biomaterials in empty space

June 25, 2021
By Tamra Sami
PERTH, Australia – Researchers at RMIT University and St. Vincent's Hospital in Melbourne have flipped traditional 3D printing to create more intricate biomedical structures, advancing new technologies for regrowing bones and tissue. Instead of making the bioscaffolds directly, the team 3D printed molds with intricately patterned cavities and then filled them with biocompatible materials, before dissolving the molds away.
Read More
Stem cells

Back to the basics for new insights, with new technology

June 25, 2021
By Anette Breindl
Sometimes, scientific progress comes from conceptual insights that arrive in a flash. More often, however, such progress arrives in a decidedly less glamorous, though no less important, manner – through the development of new technologies in what can be a very slow iterative cycle of getting a new method to work.
Read More
PolyU's biomimetic nanosheet (right), FePSe3 powder (left)

PolyU develops biomimetic nanosheet for cancer therapy and imaging

June 22, 2021
By Elise Mak
Researchers from The Hong Kong Polytechnic University said they have used two-dimensional nanosheets to develop a biomimetic nanosheet that can monitor tumor development, treat tumors and monitor the treatment progress in real-time.
Read More
Arthritis pain illustration

STING inhibitors target inflammatory diseases

June 22, 2021
A China-U.S. study led by scientists at China Pharmaceutical University (CPU) and Harvard University has identified a new small-molecule antagonist of the stimulator of interferon genes (STING) signaling pathway, SN-011, and shown it to be safe, effective and specific in STING-driven inflammatory diseases.
Read More
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