Aligos Belgium presented research on ALG-005398, a first representative of a series of non-heteroaryldihydropyrimidines (HAPs) class I capsid-assembly modulators, that was identified using structure-based drug design and scaffold hopping.
A study led by scientists at Victor Chang Cardiac Research Institute in Sydney, Australia, has shown that the transcription factor hypoxia-inducible factor 1 (HIF-1) suppresses harmful reactive oxygen species (ROS)-induced growth of cardiac fibroblasts (CFs) and fibrotic scarring after myocardial infarction (MI) in knockout (KO) mice.
A newly developed messenger RNA vaccine is the first such approach to elicit acquired resistance against the tick Ixodes scapularis and prevent it from transmitting the Lyme disease vector Borrelia burgdorferi in guinea pigs, according to a U.S. study led by researchers at Yale University School of Medicine in New Haven, Conn.
PERTH, Australia – Australian researchers have debunked previous research that suggests autism spectrum disorder behavior may be caused by differences in the composition of the gut microbiota.
Investigators from the Ragon Institute of MGH, MIT and Harvard have reported new details on a so-called exceptional elite controller, a patient who has rid herself of an HIV infection.
In contrast to most adult mammalian tissues, the liver can regenerate itself to an impressive degree. That regeneration is critical to survival – as a key digestive organ, the liver deals with all sorts of toxins, from rotten-ish food in the wild to alcohol in more cultured settings.
Researchers working at Lerner Research Institute, Cleveland Clinic reported in the November 8, 2021, issue of NatureCancer that an inhibitor of the beta-amyloid producing enzyme, BACE1, could reprogram tumor-promoting M2 macrophages to exert M1 tumor-suppressing activities in animal models of glioblastoma multiforme.
PERTH, Australia – Australian researchers have debunked previous research that suggests autism spectrum disorder behavior may be caused by differences in the composition of the gut microbiota.
A Chinese study led by scientists at Nanjing University is the first to show that modified small extracellular vesicles can cross the placenta and blood-brain barrier to target drug delivery in mice infected with the Zika virus, in which they were shown to significantly reduce fetal neurological damage, including microcephaly.
LONDON – A pilot study has shown that whole genome sequencing can pinpoint the genetic causes of rare diseases, even in people who had previously not been given a diagnosis after undergoing sequencing of their protein coding exome.
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