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Scientific data illustration

Function follows form: Predicted protein structures for human proteome now

July 23, 2021
By Anette Breindl
Researchers at Google AI company Deepmind and the European Molecular Biology Laboratory/European Bioinformatics Institute have developed and published an open-access database with predicted structures of 98.5% of proteins in the human proteome.
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Tuberculosis

Apoptosis inhibitors show promise in severe TB models

July 22, 2021
By John Fox
Macrophage and neutrophil apoptotic cell death have been demonstrated to confer resistance to severe tuberculosis (TB) infection in preclinical mouse models of the disease, according to an Australian study reported in the July 12, 2021, edition of Immunology.
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Asia at night from space

PolyU’s new polymer optical fiber sensors have multiple medical applications

July 21, 2021
By David Ho and Angie Ling
The Hong Kong Polytechnic University (PolyU) has developed new side-hole polymer optical fiber sensors, which can be used in multiple medical treatments without the drawbacks of other optical fibers used in the past. The biocompatible plastic sensors are humidity insensitive, supple and shatter-resistant. This means they can be used in various medical settings, ranging from surgical instrumentation, diagnostics to imaging equipment and sensor-based medical devices.
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HIV infected cell

All together now: Cures and reservoirs at IAS 2021

July 21, 2021
By Anette Breindl
The complete relegation of conferences to cyberspace that began with one HIV conference, CROI 2020, ended with another, the 2021 IAS meeting. Though the conference was still largely virtual, there was also an in-person component held in Berlin.
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Cardiovascular.png

CXCL9 levels predict future cardiac aging and vascular dysfunction

July 20, 2021
By W. Todd Penberthy
In the July 12, 2021, issue of Nature Aging, researchers working at the Buck Institute for Research on Aging describe analysis from 1,001 immunomes of generally healthy patients correlating soluble immune biomarkers against measures of multimorbidity, immunosenescence, frailty and cardiovascular disease over 11 years of longitudinal study.
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T cells

TGF-beta-mediated mTOR inhibition preserves cellular metabolism of precursors of exhausted T cells

July 19, 2021
Scientists at the University of Melbourne and collaborators performed an in-depth metabolic characterization of precursors of exhausted (Tpex) cells in chronic lymphocytic choriomeningitis virus infection. Their results showed that Tpex metabolic attributes strongly contrast with those of exhausted effector (Tex) cells in the same environment.
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Cancer cell and DNA

Tumor suppressor p53 is inactivated by lncRNA

July 16, 2021
By John Fox
A long noncoding RNA (lncRNA), the RNA component of mitochondrial RNA-processing endoribonuclease, was shown to promote the growth and proliferation of colorectal cancer cells by inhibiting activity of the tumor suppressor protein p53 in a Chinese study led by oncologists Fudan University Shanghai Cancer Center.
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Drug capsules in petri dish

Antibiotics double as antitumor kinase inhibitors

July 15, 2021
By Nuala Moran
New evidence about the role of the RSK family of protein kinases in cancer has cut through conflicting experimental data to demonstrate they have different functions and that the RSK4 isoform is a promoter of drug resistance and metastasis in lung and bladder cancer.
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Mammogram

Barcoding strategy tracks breast cancer metastases

July 14, 2021
By John Fox
A study led by researchers at the Olivia Newton-John Cancer Research Institute, La Trobe University, The Walter and Eliza Hall Institute, and the University of Melbourne has used a novel optical color-coding barcoded cancer cell tracking strategy to investigate metastatic heterogeneity in breast cancer.
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WHO setting up global framework to guide genome editing research

July 13, 2021
By Nuala Moran
LONDON – The World Health Organization (WHO) is to set up a channel for confidential reporting of illegal, unregistered, unethical or unsafe human genome editing research, as part of a new governance framework it is proposing to develop.
Read More
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