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Human cell illustration

Mutational profiling gives clues to development, new puzzles about disease

Aug. 25, 2021
By Nuala Moran
The family trees of different cell types from different tissues and organs have been traced back to the fertilized egg that gave rise to the human body of which the cells formed a part, establishing a baseline for “normal” development and aging that could help improve understanding of the onset of disease.
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Petri dish and capsules

Moving side chains amps up peptides' infection-fighting abilities

Aug. 25, 2021
By Subhasree Nag and Anette Breindl
A team of researchers has created peptide-like molecules – "peptoids" – with antiviral properties that could circumvent the naturally occurring antimicrobial peptides' shortcomings.
Read More
Brain and DNA

Gene therapy ameliorates androgen receptor-driven neuromuscular disease

Aug. 24, 2021
By Anette Breindl
For most people, neither polyglutamine disorders nor neuromuscular disorders are likely to be among the things they associate with androgen receptor (AR) dysfunction. But the three are indeed linked. And researchers have reported new insights into the nature of those links that could lead to a treatment for spinal and bulbar muscular atrophy, and possibly other disorders linked to AR signaling dysfunction.
Read More
Single strand RNA

New delivery system SENDs therapeutic RNA without triggering immune system

Aug. 24, 2021
By Anette Breindl
Investigators at MIT have identified a protein capable of delivering its own mRNA to cells, and engineered that protein to deliver mRNA sequences of their choosing.
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Cancer cells under magnifying glass

Cytokine-induced JAK/STAT signaling plays role in cachexia

Aug. 23, 2021
By Subhasree Nag
A multidisciplinary team of researchers has identified Upd3, a cytokine, as an important modulator of tumor growth and host wasting via activation of JAK/STAT signaling.
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Brain and DNA

Gene therapy ameliorates androgen receptor-driven neuromuscular disease

Aug. 20, 2021
By Anette Breindl
For most people, neither polyglutamine disorders nor neuromuscular disorders are likely to be among the things they associate with androgen receptor (AR) dysfunction. But the three are indeed linked. And researchers have reported new insights into the nature of those links that could lead to a treatment for spinal and bulbar muscular atrophy, and possibly other disorders linked to AR signaling dysfunction.
Read More
DNA NGS genome sequencing

Rare gene variants increase zoonotic H7N9 susceptibility

Aug. 20, 2021
By John Fox
A whole genome sequencing study has been the first to demonstrate a strong association between infection with the avian influenza A virus H7N9 and rare, heterozygous single-nucleotide variants in the MX1 gene encoding for the myxovirus resistance protein A.
Read More
Diagram

Weak magnetic fields boost formation of new blood vessels using mesenchymal stromal cells

Aug. 19, 2021
By Bernard Banga
PARIS – Magnetic fields can be used to stimulate blood vessel growth, according to a new study published in Science and Technology of Advanced Materials. The discovery, by researchers from the University of Lisbon in Portugal, could lead to new treatments for cancer and help regenerate tissues that have lost their blood supply.
Read More
Long COVID word cloud

‘Not just the flu’ holds for SARS-CoV-2 long-term effects, too

Aug. 19, 2021
By Anette Breindl
When SARS-CoV-2 first emerged in 2020, with respiratory symptoms as the most obvious feature of infection, the most obvious comparison was to influenza. COVID-19, of course, was never just another flu.
Read More
Silhouette of head, brain

Stress hormones affect brain plasticity via distinct mechanisms

Aug. 18, 2021
By Anette Breindl
Researchers have shown that glucocorticoids, a type of steroid hormones, target both neuroplasticity-related genes and genes related to ciliary function in the brain. However, the effects on the different processes are mediated via different receptors, and in response to different stimuli. A study investigated the specific targets of glucocorticoids, giving new insights into the biological mechanisms of stress adaptations, and how they are linked to neural plasticity.
Read More
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