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Blood-brain barrier illustration

Complexes cross BBB, knock down CNS genes in rodents

Aug. 18, 2021
By John Fox
A Japanese study has discovered a new means of regulating endogenous gene expression in the CNS, using systemically administered antisense oligonucleotides (ASOs) in rodents, which facilitates development of ASO-based therapies for patients with neurological diseases requiring prolonged treatment.
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Cancer biopsy slide

Scientists travel the ‘collagen highway’ to predict and prevent recurrent breast cancer

Aug. 17, 2021
By David Godkin
Scientists at Cleveland-based Case Western Reserve University have used artificial intelligence (AI) to identify biomarkers contained in naturally occurring collagen that could predict whether breast cancer will return after treatment. Identified from standard tissue biopsy slides of early-stage breast cancer, collagen-based assays could also be less expensive than gene expression-based assays typically conducted at highly specialized labs in California.
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Tiger mosquito

Aberrant NAD+ metabolism underlies Zika microcephaly

Aug. 17, 2021
By John Fox
A multi-omics analysis led by Chinese scientists at Tsinghua University in Beijing has demonstrated that aberrant metabolism of the co-enzyme nicotinamide adenine dinucleotide (NAD+) was responsible for microcephaly induced by Zika virus infection during pregnancy.
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Human anatomy

Polymer-mediated "immunocloaking" - A new paradigm for combating transplant rejection?

Aug. 16, 2021
By Subhasree Nag
Organ transplantation is often a life-saving intervention whose success is mediated by the host's immune system. Immune-mediated rejection of an organ transplant destroys the transplanted organ or tissue and can be fatal.
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RNA

lncRNA HULC linked to phenylketonuria prevention, HULC-mimetics show therapeutic promise

Aug. 13, 2021
By W. Todd Penberthy
Sometimes highly impactful serendipitous discoveries are made when performing genetic loss-of-function studies that were initially focused on putative tumor suppressors or other hypotheses.
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Microscope and coronavirus illustration

Marker of neuroaxonal injury is also a marker of worse outcomes in COVID-19 patients

Aug. 12, 2021
A proportion of patients with COVID-19 develop neurological symptoms, including headaches, encephalopathy and seizures, but it is unknown to which extent.
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Illustration of cancer cells and immunotherapy treatment

Resveratrol-triggered switches maximize cancer immunotherapy, reduce toxicity

Aug. 11, 2021
By John Fox
Resveratrol-triggered genetic switches, which can control in vivo tumor-targeted chimeric antigen receptor T-cell (CAR T) therapy, have been developed by Chinese researchers, who demonstrated that the new tools enabled maximized in vivo immunotherapeutic efficacy while minimizing toxicity.
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Graphene illustration

Graphene coating may prevent the formation of biofilms on medical implants

Aug. 10, 2021
By Nuala Moran
LONDON – Swedish researchers have devised a method for binding insoluble antibiotics to graphene coatings, in an advance that could prevent the formation of biofilms on medical implants. In comparison to other long-winded methods for loading antibiotics onto implant surfaces, they say the way in which they bind active molecules to graphene is simple and could easily be integrated into manufacturing processes.
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Silhouette of head, brain

Stress hormones affect brain plasticity via distinct mechanisms

Aug. 10, 2021
By Anette Breindl
Researchers have shown that glucocorticoids, a type of steroid hormones, target both neuroplasticity-related genes and genes related to ciliary function in the brain. However, the effects on the different processes are mediated via different receptors, and in response to different stimuli. A study investigated the specific targets of glucocorticoids, giving new insights into the biological mechanisms of stress adaptations, and how they are linked to neural plasticity.
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T cells

T-cell exhaustion is durable, but specific

Aug. 9, 2021
By Anette Breindl
It's a good news, bad news scenario for exhausted T cells in chronic infections. Multiple groups of investigators reported in the July 26, 2021, online issue of Nature Immunology that even after a chronic hepatitis C virus infection was cured, T cells that had become dysfunctional during the infection retained epigenetic "scars" that prevented them from becoming fully functional memory T cells.
Read More
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