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Amyloid plaque on nerve cell

In vivo gene editing alleviates amyloid pathologies

July 30, 2021
By John Fox
Brain-wide genome editing via a single systemic dose of modified adeno-associated virus variants that cross the blood-brain barrier may represent a promising new approach for the development of disease-modifying treatments for familial Alzheimer's disease.
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Neurons

Restoring chondroitin 6-sulfate can rescue age-related memory impairment

July 29, 2021
A team of researchers from the University of Cambridge and collaborating institutions hypothesized that the age-related increase in the ratio of C4S/C6S may make perineuronal nets more inhibitory, leading in turn to memory loss associated with diminished inhibitory synapse formation onto GABAergic parvalbumin+ interneurons.
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T cells

T-cell exhaustion is durable, but specific

July 28, 2021
By Anette Breindl
It's a good news, bad news scenario for exhausted T cells in chronic infections. Multiple groups of investigators reported in the July 26, 2021, online issue of Nature Immunology that even after a chronic hepatitis C virus infection was cured, T cells that had become dysfunctional during the infection retained epigenetic "scars" that prevented them from becoming fully functional memory T cells.
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Cancer cell and DNA

Yeast study reveals potential cancer therapy approach

July 27, 2021
By John Fox
Research into how gross chromosomal rearrangements occur may have major implications for the discovery and development of new cancer therapies, according to a Japanese study reported in the July 22, 2021, edition of PLoS Genetics
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Brain illustration

International researchers develop dementia diagnostic algorithm

July 26, 2021
By Annette Boyle
Researchers from Finland and Italy published a biomarker-based algorithm for the diagnosis of dementia in the journal Diagnostics. The algorithm enables clinicians to distinguish between various neurodegenerative diseases with shared clinical presentations and select appropriate treatment. The algorithm relies primarily on blood biomarker measurements to diagnose the type of dementia much earlier than is possible with the diagnostic tools in use today.
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Liver

Enteric HDL shown to prevent liver injury via portal vein

July 26, 2021
By John Fox
A high-density lipoprotein (HDL) subspecies produced by small intestine, which potently shields the endotoxicity of bacterial lipopolysaccharide (LPS), may protect against gut-derived liver injury, according to a study led by scientists at Washington University School of Medicine (WUSM) in St. Louis.
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Scientific data illustration

Function follows form: Predicted protein structures for human proteome now

July 23, 2021
By Anette Breindl
Researchers at Google AI company Deepmind and the European Molecular Biology Laboratory/European Bioinformatics Institute have developed and published an open-access database with predicted structures of 98.5% of proteins in the human proteome.
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Tuberculosis

Apoptosis inhibitors show promise in severe TB models

July 22, 2021
By John Fox
Macrophage and neutrophil apoptotic cell death have been demonstrated to confer resistance to severe tuberculosis (TB) infection in preclinical mouse models of the disease, according to an Australian study reported in the July 12, 2021, edition of Immunology.
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Asia at night from space

PolyU’s new polymer optical fiber sensors have multiple medical applications

July 21, 2021
By David Ho and Angie Ling
The Hong Kong Polytechnic University (PolyU) has developed new side-hole polymer optical fiber sensors, which can be used in multiple medical treatments without the drawbacks of other optical fibers used in the past. The biocompatible plastic sensors are humidity insensitive, supple and shatter-resistant. This means they can be used in various medical settings, ranging from surgical instrumentation, diagnostics to imaging equipment and sensor-based medical devices.
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HIV infected cell

All together now: Cures and reservoirs at IAS 2021

July 21, 2021
By Anette Breindl
The complete relegation of conferences to cyberspace that began with one HIV conference, CROI 2020, ended with another, the 2021 IAS meeting. Though the conference was still largely virtual, there was also an in-person component held in Berlin.
Read More
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