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Herpes simplex virus

HSV-targeting compound affects latent infection

June 18, 2021
By Anette Breindl
A German-American team of researchers has developed a compound that could affect latent herpes simplex virus (HSV) infections, reducing the risk of recurrence even after an infection had fully established itself in its neuronal reservoir.
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Acetaminophen pills

Tylenol could find role in gene therapy

June 17, 2021
By Anette Breindl
Researchers at Oregon Health & Science University have turned acetaminophen's toxicity into an asset, using it to select genetically modified hepatocytes in vivo.
Read More
Cancer cells

Switching on prodrugs with radiotherapy shows promise

June 17, 2021
By John Fox
Local tumor conversion of a prodrug to an active agent using clinically relevant radiotherapy may herald a new era in targeted and directed cancer chemotherapy.
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Acetaminophen pills

Tylenol could find role in gene therapy

June 16, 2021
By Anette Breindl
Researchers at Oregon Health & Science University have turned acetaminophen's toxicity into an asset, using it to select genetically modified hepatocytes in vivo.
Read More
Prostate cancer cells

Prostate cancers illustrate equity’s prerequisites at ASCO 2021

June 15, 2021
By Anette Breindl
At the 2021 virtual annual meeting of the American Society for Clinical Oncology (ASCO), results of the VISION trial testing the addition of Novartis AG’s radiopharmaceutical Lutetium-177-PSMA-617 (Lutetium-PSMA) to individualized standard-of-care regimens in metastatic castration-resistant prostate cancer improved both overall survival and radiographic progression-free survival.
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3D printing illustration

New 3D printing process to tailor-make medical devices combats bacterial resistance

June 15, 2021
By Ana Mulero
A new 3D printing technique has allowed University of Nottingham researchers to tailor-make artificial body parts and other medical devices that are both implantable and bacteria-resistant. The multi-materials manufactured in the study were also adapted to 3D printing technology that is able to offer devices that can better meet the need of the patient and minimize the surgeries led by device failure that increase the risk of infections.
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3D heart in chest

Sirtuin affects cardiac lipotoxicity via secondary mechanism

June 15, 2021
By Subhasree Nag
Sirtuins, which are a highly conserved family of NAD+-dependent deacetylases, have been shown to be involved in a wide range of physiological and pathological processes, including aging, energy responses to low calorie availability and stress resistance, as well as apoptosis and inflammation.
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Liver

New target identified for acetaminophen liver injury

June 14, 2021
By John Fox
An international study led by scientists at Duke-NUS Medical School in Singapore has identified signaling for the cytokine IL-11 as representing a potential new therapeutic target for acetaminophen-induced liver injury in mouse models.
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Silhouette with AI illustration

Having to explain itself makes for better AI decisions

June 11, 2021
By Anette Breindl
Researchers at the University of Washington reported in the May 31, 2021, issue of Nature Medicine that artificial intelligence (AI) algorithms meant to recognize COVID-19 infections based on chest X-rays picked up on confounders, selecting “shortcuts” such as patient age or positioning in the X-ray as a basis for their predictions.
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Brain teaser

Myelin renewal reverses AD cognitive dysfunction in mice

June 11, 2021
By John Fox
Researchers have demonstrated that enhancing myelin renewal in the brains of transgenic APP/PS1 mouse models of Alzheimer's disease (AD) can improve their task-related hippocampal activity.
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