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BioWorld - Friday, July 17, 2026
Home » Topics » Clinical

Clinical
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Vials, syringes, pills and masks

WHO selects vaccines, therapeutics for Ebola outbreak field trials

May 29, 2026
By Nuala Moran
No Comments
“I need to be honest with you about something important. Most previous Ebola outbreaks in the Democratic Republic of Congo (DRC) were caused by a virus called Ebola Zaire, for which we have vaccines and treatments. This outbreak is caused by a different virus called Ebola Bundibugyo. There are currently no approved vaccines or treatments for it.” This was the stark message from Tedros Adhanom Ghebreyesus, director general of the World Health Organization (WHO) in an open letter to the people of the DRC, as he traveled to the country on Friday, May 29.
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Healthy (left) vs. cancerous bone marrow
ASCO 2026

BMS’ mezigdomide doubles PFS in multiple myeloma

May 29, 2026
By Brian Orelli
No Comments
Bristol Myers Squibb Co. disclosed in March 2026 that the phase III portion of the seamless phase II/III Successor-2 study testing mezigdomide in combination with carfilzomib and dexamethasone (MeziKd) in patients with relapsed or refractory multiple myeloma was successful. Nearly three months later, the magnitude of success for its Pomalyst (pomalidomide) successor is clear.
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Liver with hepatitis viruses, blood cells

Breakthrough as GSK’s bepirovirsen clears 19% of chronic hep B infections

May 28, 2026
By Nuala Moran
No Comments
GSK plc has announced a breakthrough in the treatment of chronic hepatitis B, reporting a functional cure rate of 19% across two phase III trials of its antisense oligonucleotide bepirovirsen.
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Art concept for liver damage, such as fatty liver, fibrosis or cirrhosis

D&D’s zabopegdutide shows more upbeat top-line phase II MASH data

May 27, 2026
By Marian (YoonJee) Chu
No Comments
D&D Pharmatech Inc. announced May 27 positive top-line tissue biopsy results of zabopegdutide (DD-01) from a 48-week phase II study of metabolic dysfunction-associated steatohepatitis (MASH), pushing company shares up 30% on the day.
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Close up dermatitis on the skin

Apogee orbiting big AD market as Apex phase II data land

May 27, 2026
By Randy Osborne
No Comments
Apogee Therapeutics Inc. loaded up on what could total as much as $1.3 billion in financial fuel from Blackstone Life Sciences funds that will be used to propel zumilokibart (zumi), which yielded positive phase II results in atopic dermatitis (AD). A phase III experiment with the anti-IL-13 antibody is planned for the second half of this year, pending talks with regulators.
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Ebola virus in petri dish with lab, scientist background

Work underway on vaccines, antivirals against rare Bundibugyo Ebola outbreak

May 26, 2026
By Nuala Moran
No Comments
Less than two weeks after the outbreak was officially declared, animal studies of a newly designed vaccine against the Bundibugyo Ebola virus are now underway in the U.S. and U.K., and the Serum Institute of India is standing ready to manufacture the vaccine for clinical trials. If the animal tests are positive, the vaccine will be ready for clinical trials in two to three months.
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Syringes in virus cell; Lilly, Curevo, Limmatech, Vaccine Company   logos

Lilly buys three vaccine makers; PCSK9 base editor shows promise

May 26, 2026
By Karen Carey
No Comments
As the most active biopharma acquirer of 2026, Eli Lilly and Co. offered to buy three vaccine companies for up to $3.8 billion combined, while it simultaneously released positive early clinical results of a gene editing medicine brought into the fold last year through its buyout of Verve Therapeutics Inc.
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Illustration of cancer in the pancreas

MEK inhibitor delivers 17.3-month OS for pancreatic cancer

May 22, 2026
By Karen Carey
No Comments
Immuneering Corp. reported a median overall survival of 17.3 months in first-line metastatic pancreatic cancer patients treated with its MEK inhibitor atebimetinib (IMM-1-104) plus modified gemcitabine/nab-paclitaxel in a phase IIa trial. Mizuho analyst Graig Suvannavejh called the results “astounding … easily beating current standard-of-care treatments.”
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Lung infection caused by bacteria Pseudomonas aeruginosa

Infex has positive phase IIa data in bronchiectasis; preps for next trial

May 21, 2026
By Nuala Moran
No Comments
Infex Therapeutics Ltd. has published positive phase IIa data for its lead program, RESP-X, in the treatment of exacerbations of chronic respiratory infections caused by Pseudomonas aeruginosa and is now laying the ground for phase IIb development, after raising £4.3 million (US$5.8 million) in new capital.
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Feet on scale and measuring tape

Another Triumph: Lilly’s triple G agonist scores in obesity

May 21, 2026
By Karen Carey
No Comments
Posting another win for its triple G agonist, Eli Lilly and Co. rolled out top-line phase III data from Triumph-1 showing that all doses of retatrutide met primary and key secondary endpoints for obesity, with participants losing on average between 19% and 28.3% of body weight and significantly improving their cardiovascular risk factors.
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