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BioWorld - Wednesday, May 31, 2023
Home » Topics » Clinical

Clinical
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3d illustration of ovarian cancer

Junshi Bioscience’s PARP inhibitor, senaparib, meets endpoint in phase III ovarian cancer trial

April 18, 2023
By Tamra Sami
No Comments
Junshi Biosciences Co. Ltd.’s PARP inhibitor, senaparib (JS-109/IMP4297), met the primary endpoint of progression-free survival in a phase III ovarian cancer study, according to a prespecified interim analysis.
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Concept image for Lewy bodies in neurons

Biomarker identifies Parkinson’s before symptoms appear

April 17, 2023
By Annette Boyle
No Comments
A biomarker found in spinal fluid can detect Parkinson’s disease in individuals with the disease and may flag those at risk years before symptoms develop, a study published in The Lancet Neurology found. The breakthrough, which could enable diagnosis of the disease for the first time in patients who do not exhibit a movement disorder, was achieved by an international coalition of scientists led by the Michael J. Fox Foundation (MJFF) as part of its landmark clinical study, the Parkinson’s Progression Markers Initiative (PPMI).
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AACR 2023: Cancer vaccine trial results elicit reactions from 'indisputable' to 'cautious optimism'

April 17, 2023
By Anette Breindl
No Comments
Combining the personalized cancer vaccine mRNA-4157 (V-940, Moderna Inc.) with Keytruda (pembrolizumab, Merck & Co. Inc.) significantly extended recurrence-free survival in patients with stage III/IV resected high-risk melanoma in the randomized phase II KEYNOTE-942/mRNA-4157-P201 trial. Compared to Keytruda alone, adding the vaccine cut the risk of recurrence or death by 44% 18 months after treatment, lead investigator Jeffrey Weber reported at the opening clinical trials plenary of the 2023 annual meeting of the American Association for Cancer Research (AACR).
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3d illustration of ovarian cancer

Junshi Bioscience’s PARP inhibitor, senaparib, meets endpoint in phase III ovarian cancer trial

April 13, 2023
By Tamra Sami
No Comments
Junshi Biosciences Co. Ltd.’s PARP inhibitor, senaparib (JS-109/IMP4297), met the primary endpoint of progression-free survival in a phase III ovarian cancer study, according to a prespecified interim analysis.
Read More
Illustration of blood vessel that isn't clotting due to hemophilia

New imaging method for evaluating blood flow

April 12, 2023
By Shani Alexander
No Comments
A new method for imaging microvascular blood flow which will allow for better diagnosis of vascular diseases such as diabetic foot ulcers has been developed by researchers from the department of biomedical engineering at Linkoping University, Sweden, in cooperation with Perimed AB.
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Lung cancer illustration

Immutep’s LAG-3 efti plus pembrolizumab extends efficacy in NSCLC

April 12, 2023
By Tamra Sami
No Comments
Immutep Ltd.’s lead immunotherapy candidate, eftilagimod (IMP-321, efti), plus pembrolizumab reverted previous resistance to PD-1/PD-L1 therapy in part B of the TACTI-002 phase II trial in second-line metastatic non-small-cell lung cancer (NSCLC) in patients refractory to anti-PD-1/PD-L1 therapy.
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Moderna needs more sick people for its phase III flu study

April 11, 2023
By Lee Landenberger
No Comments
On Vaccine Day, Moderna Inc. had to tell the world there weren’t enough flu cases to get a good reading in one of its two phase III vaccine studies. The northern hemisphere clinical trial of mRNA-1010, a seasonal quadrivalent vaccine, did not meet the statistical threshold because there were not enough sick participants to test to determine an interim efficacy analysis.
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Kidneys

CD38 special in more ways than one; Hi-Bio shoots down kidney disorder in phase II trials

April 11, 2023
By Randy Osborne
No Comments
Human Immunology Biosciences Inc. (Hi-Bio) is moving ahead to late-stage work after disclosing positive phase II data from two trials testing the monoclonal antibody felzartamab for primary membranous nephropathy (PMN), a rare autoantibody-mediated autoimmune kidney disease and a leading cause of nephrotic syndrome. CEO Travis Murdoch told BioWorld that his firm is “working through designs for the next study, and planning to engage with regulators,” after which more details will be shared. PMN, he added, has “not been heavily trodden, but increasingly there’s a recognition that there’s an important patient and commercial opportunity” in the indication.
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Noxopharm quits development of Veyonda, reduces headcount as stock plummets nearly 40%

April 11, 2023
By Tamra Sami
No Comments
Noxopharm Pty Ltd.’s stock plummeted nearly 40% on the morning of April 6 after the company announced it was quitting development of its lead program, Veyonda (idronoxil/formerly OX-66), shuttering its DARRT-2 and CEP-2 oncology clinical trials and disbanding its clinical trial team to contain costs.
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Optogenetics illustration

PYC Therapeutics enters clinic with RNA therapy for retinitis pigmentosa

April 11, 2023
By Tamra Sami
No Comments
PYC Therapeutics Ltd.’s lead candidate, VP-001, is entering the clinic, and the RNA therapy could be the first potential treatment for retinitis pigmentosa type 11, which causes blindness that begins in childhood and ultimately leads to legal blindness by middle age.
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