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BioWorld - Thursday, January 1, 2026
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Working backward from the goal is promising HIV vaccine strategy

July 30, 2024
By Anette Breindl
The 2024 meeting of the International AIDS Society (IAS) is wrapping up as the 2024 Olympic Games are about to begin. That timing was probably what prompted the use of multiple sports analogies at Thursday’s plenary session on HIV prevention strategies.
Read More
Elderly hands holding broken brain structure

Despite endpoint miss, Cognition sees path forward in Alzheimer’s

July 29, 2024
By Jennifer Boggs
Cognition Therapeutics Inc. said it is moving to the next stage of clinical testing with oral, small-molecule candidate CT-1812, despite phase II efficacy results falling short of statistical significance in patients with mild to moderate Alzheimer’s disease and sending shares of the Purchase, N.Y.-based company (NASDAQ:CGTX) falling 44%, or $1.04, to close July 29 at $1.33.
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Syringe with illustration of molecules
HIV/AIDS

Working backward from the goal is promising HIV vaccine strategy

July 29, 2024
By Anette Breindl
Last week, the 2024 meeting of the International AIDS Society (IAS) was wrapping up as the 2024 Olympic Games were about to begin. That timing was probably what prompted the use of multiple sports analogies at Thursday’s plenary session on HIV prevention strategies. Given the decades-long attempts at developing an HIV vaccine, Peter Piot, past IAS president and director emeritus and professor at the London School of Hygiene and Tropical Medicine, said in his introduction: “This is clearly a marathon. But marathons also finish.”
Read More
Colorful illustration of the heart
Cardiovascular

EDG-7500 improves diastolic performance in animal models of pacing induced LV systolic dysfunction

July 29, 2024
Researchers from Edgewise Therapeutics Inc. presented preclinical data for the cardiac sarcomere modulator, EDG-7500, which is being developed for the treatment of hypertrophic cardiomyopathy (HCM) and other diseases of diastolic dysfunction.
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Working backward from the goal is promising HIV vaccine strategy

July 26, 2024
By Anette Breindl
The 2024 meeting of the International AIDS Society (IAS) is wrapping up as the 2024 Olympic Games are about to begin. That timing was probably what prompted the use of multiple sports analogies at Thursday’s plenary session on HIV prevention strategies. Given the decades-long attempts at developing an HIV vaccine, Peter Piot, past IAS president and director emeritus and professor at the London School of Hygiene and Tropical Medicine, said in his introduction: “This is clearly a marathon. But marathons also finish.”
Read More
Illustration of herpes simplex virus particles
Infection

Long-acting helicase-primase inhibitor prevents HSV recurrences

July 26, 2024
Half of the individuals with genital herpes simplex virus (HSV) infection experience several recurrence episodes per year, especially if the causative agent is HSV type 2 (HSV-2). Standard-of-care viral DNA polymerase inhibitors are not fully effective in preventing recurrences and managing symptoms.
Read More
Illustration of human heart with DNA structure background
Cardiovascular

LX-2020 gene therapy reverses severe cardiomyopathy in mice

July 25, 2024
Arrhythmogenic cardiomyopathy (ACM) is a severe genetic cardiac disorder caused by mutations in some desmosomal genes. The most frequently affected gene in patients with ACM is PKP2, the loss of which provokes desmosomal instability that leads to activation of downstream disease processes ultimately resulting in life-threatening ventricular arrhythmia and heart failure.
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HIV drugs
HIV/AIDS

Gilead’s GS-1720 permits once-weekly oral administration

July 25, 2024
Integrase strand transfer inhibitors (INSTI) under a once-daily oral schedule are the standard-of-care treatment for HIV. Longer-acting oral and injectable formulations to facilitate adherence to treatment regimens are needed.
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Cross section illustration of HIV virus parts
HIV/AIDS

IAS 2024: Seventh HIV cure reported, but broad reach will take other approaches

July 22, 2024
By Anette Breindl
The 2024 meeting of the International AIDS Society (IAS), which is being held in Munich this week, began with the announcement of another curative bone marrow transplant. The new case brings the total number of patients cured of HIV via a bone marrow transplant up to 7 since “Berlin patient” Timothy Ray Brown became the first such person in 2007.
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Optogenetics illustration

4D, Adverum phase IIs inflame AMD gene therapy space

July 17, 2024
By Randy Osborne
As the hunt goes on for a better treatment in wet age-related macular degeneration (AMD), landmark analyses of two batches of phase II gene therapy data billed as positive were disclosed during the American Society of Retina Specialists annual meeting in Stockholm, where 4D Molecular Therapeutics Inc. and Adverum Biotechnologies Inc. offered findings.
Read More
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