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Home » Topics » American College of Rheumatology, BioWorld Science

American College of Rheumatology, BioWorld Science
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Immune

S-4321, a dual-cell bidirectional antibody that agonizes inhibitory receptors at the T cell-APC synapse

Dec. 4, 2024
Seismic Therapeutic Inc. has provided preclinical data for S-4321, a novel dual-cell bidirectional (DcB) PD-1:FcγRIIb antibody being developed for the treatment of autoimmune disease.
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Immune

Kronos Bio’s KB-7898 reduces pathological scores in inflammatory disorders

Dec. 4, 2024
Kronos Bio Inc. has presented data on KB-7898, an orally available p300 KAT inhibitor.
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Immune

PAI-1 inhibitor MDI-2517 shows superior preclinical efficacy in systemic sclerosis models

Dec. 3, 2024
Researchers from the University of Michigan Medical School and MDI Therapeutics Inc. recently presented preclinical data for MDI-2517.
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Joint pain illustration
Inflammatory

Oral STAT3 inhibitor shows promising efficacy and safety profile in model of inflammatory arthritis

Dec. 2, 2024
Scientists from Recludix Pharma Inc. presented the preclinical characterization of REX-7117, an orally available, reversible, SH2 domain-targeting STAT3 inhibitor, being developed for the treatment of inflammatory diseases.
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B-cell releasing antibodies
Immune

Kyverna’s KYV-102 has potent CAR therapeutic activity

Dec. 2, 2024
Kyverna Therapeutics Inc. has presented details on the development and preclinical characterization of KYV-102, an autologous fully human anti-CD19 CAR T-cell therapy developed for diseases driven by B cells, such as systemic lupus erythematosus (SLE), among others.
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Immune

M-5542 shows promise in the treatment of GVHD

Nov. 29, 2024
Researchers from EMD Serono Research and Development Institute Inc. hypothesized that modulation of two T-cell costimulatory pathways, such as CD28 and OX40, in one single molecule would be more efficient at controlling T-cell activation than modulating each pathway separately.
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Red CAR T cell on blue blackground
Immune

Allogene’s ALLO-329 shows efficacy at killing CD19- and CD70-expressing cells

Nov. 28, 2024
To address limitations with CAR T therapies targeting CD19, Allogene Therapeutics Inc. has developed ALLO-329, a CD19/CD70-targeting CAR therapy that is able to deplete activated alloreactive lymphocytes, while endowing dual targeting of CD19+ B cells and CD70+ T cells.
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Immune

S-1117, an Fc-fused IgG degrading enzyme, shows safety after chronic dosing in mice

Nov. 27, 2024
Seismic Therapeutic Inc.'s S-1117 was designed as a pan-IgG protease fused to an effector function silent human IgG1 Fc domain. The candidate, being developed for the treatment of autoantibody-mediated diseases, was engineered for chronic subcutaneous administration using a proprietary machine learning-enabled platform, with the aim of reducing immunogenicity while maintaining potency.
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Doctor holding illustration of cross section of skin
Dermatologic

DB-2304 has strong in vivo potency in psoriasis models

Nov. 25, 2024
Blood dendritic cell antigen 2 (BDCA2) is expressed in plasmacytoid dendritic cells. These cells’ overproduction of type I interferon is closely linked to the pathogenesis of systemic lupus erythematosus and other autoimmune diseases.
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Joint pain
Musculoskeletal

Gilead’s GS-6791 ameliorates arthritis symptoms in mice

Nov. 21, 2024
Interleukin-1 receptor-associated kinase 4 is critical in the modulation of inflammatory responses through Toll-like receptor and IL-1R signaling.
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