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Home » Topics » American College of Rheumatology, BioWorld Science

American College of Rheumatology, BioWorld Science
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Close up of senior man holding wrist of arthritic hand
Musculoskeletal

TNF-α/OX40L bispecific antibody shows efficacy in models of rheumatoid arthritis

Nov. 28, 2023
Researchers from Seoul National University presented results of preclinical evaluation of a new TNF-α/OX40L bispecific antibody, IMB-101, being developed for the treatment of rheumatoid arthritis (RA).
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3D illustration of knee joint
Musculoskeletal

Innovo Therapeutics’ INV-1498 shows efficacy in canine osteoarthritis model

Nov. 27, 2023
Treatment of osteoarthritis (OA) is still a challenge, since it is focused on symptom relief but fails at dealing with the progressive cartilage deterioration that occurs during the disease. Researchers from Innovo Therapeutics Inc. recently unveiled INV-1498, a caspase inhibitor, as a preclinical candidate for the treatment of OA.
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Arthritis pain illustration
Inflammatory

New RIPK2 scaffolding inhibitor selectively blocks microbe-induced inflammation

Nov. 24, 2023
Inhibition of receptor-interacting serine/threonine-protein kinase 2 (RIPK2) has been previously described as a promising strategy for the treatment of inflammatory bowel disease, as RIPK2 is a key player in the signaling leading to bacterial peptidoglycan (PGN)-induced inflammation and it amplifies pro-inflammatory responses in the intestine.
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Drug R&D concept image.
Immune

Anti-CD19 KYV-101 shows promise for autoimmune diseases

Nov. 20, 2023
Researchers from Kyverna Therapeutics Inc. have presented data on their anti-CD19 CAR T-cell therapy, KYV-101, for the treatment of B-cell-driven autoimmune diseases.
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Close up of hand scratching arm with psoriasis patches
Dermatologic

Guangzhou Fermion Technology presents data on TYK2 inhibitor

Nov. 17, 2023
Nonreceptor tyrosine-protein kinase TYK2 plays key roles in the signaling of pro-inflammatory molecules such as IL-23, IL-12 or type I IFN, which at the same time play key roles in several immune-mediated diseases such as atopic dermatitis and psoriasis, among others.
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Musculoskeletal

TLR7-targeting antibody shows promise in SLE treatment

Nov. 16, 2023
There is increasing evidence on the involvement of Toll-like receptor 7 (TLR7) in the pathogenesis of systemic lupus erythematosus (SLE). At the recent American College of Rheumatology meeting, researchers from Daiichi Sankyo Co. Ltd. presented preclinical data on DS-7011a, a TLR7 antagonist antibody with for the potential treatment of SLE.
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