SAN FRANCISCO – Type 2 diabetes often becomes progressively more difficult to manage, moving from prediabetes that can be addressed via weight loss and exercise eventually through requiring multiple daily insulin injections. A novel procedure could offer the opportunity to turn back the clock for type 2 (T2) diabetes patients who are insulin-dependent. Fractyl Laboratories Inc. has developed an outpatient procedure known as duodenal mucosal resurfacing (DMR) that, when used in combination with a GLP-1 receptor agonist drug, can reverse the need for insulin for type 2 diabetes patients who were previously insulin-dependent. That's according to data from a small study presented here on June 9 at the American Diabetes Association's 79th Scientific Sessions.

At a family wedding earlier this month, an uncle was salivating over the prospect that the Vivus Inc. drug Qnexa could soon become the first in a new generation of obesity drugs to gain FDA approval. He needed to lose 50 pounds, he confided, and the drug seemed the answer to his prayers. Since we’ve written extensively about obesity and these drugs in BioWorld Today, he wanted my opinion. I politely inquired whether he had considered dieting and exercise, which could produce similar results without the potential side effects of a prescribed drug – especially one in a category that’s...