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Home » Topics » Disease categories and therapies » Endocrine/metabolic

Endocrine/metabolic
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Cholesterol plaque in artery
Cardiovascular

PPRHs lower levels of PCSK9 and cholesterol in transgenic mouse without causing toxicity

June 19, 2025
No Comments
Researchers from the Universitat de Barcelona and Oregon Health & Science University have developed a novel gene silencing technique using polypurine reverse Hoogsteen hairpins (PPRH) to target and inhibit the expression of PCSK9.
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Tape measure wrapped around scale
Endocrine/metabolic

Biomea Fusion’s BMF-650 yields weight loss, appetite suppression in nonhuman primates

June 19, 2025
No Comments
Biomea Fusion Inc. has released preclinical findings from a 28-day weight loss study in obese nonhuman primates evaluating BMF-650, a next-generation oral small-molecule glucagon-like peptide-1 receptor agonist (GLP-1RA).
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Endocrine/metabolic

New GLP-1R agonists disclosed in Hengrui patent

June 18, 2025
Scientists at Jiangsu Hengrui Pharmaceuticals Co. Ltd. and Shanghai Hengrui Pharmaceutical Co. Ltd. have divulged glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of type 1 diabetes, atherosclerosis, type 2 diabetes, obesity, nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH), hypertension, diabetic complications and coronary heart disease among others.
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Endocrine/metabolic

Ascletis Pharma discovers new GLP-1R agonists

June 17, 2025
Ascletis Pharma (China) Co. Ltd. has described glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH), diabetes, obesity, metabolic syndrome and more.
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Obesity, fat cell research concept image
Endocrine/metabolic

Ibio nominates IBIO-610 as obesity development candidate

June 17, 2025
No Comments
Ibio Inc. has nominated IBIO-610 as a development candidate for its first-in-class Activin E antibody program and initiated a nonhuman primate (NHP) study.
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Tape measure, apple on scale
Endocrine/metabolic

MBX Biosciences files IND application for MBX-4291 for obesity

June 17, 2025
No Comments
MBX Biosciences Inc. has submitted an IND application to the FDA for MBX-4291, a long-acting glucagon-like peptide-1 (GLP-1)/ glucose-dependent insulinotropic polypeptide (GIP) receptor co-agonist prodrug for the treatment of obesity.
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Kidneys
Endocrine/metabolic

ISG15 elevation induces diabetic kidney disease, study finds

June 17, 2025
No Comments
Diabetic kidney disease (DKD) is a chronic complication of type 1 and type 2 diabetes with albuminuria and progressive kidney failure; about 20%-40% of patients with diabetes will develop some type of kidney disease.
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Endocrine/metabolic

Haisco Pharmaceutical patents new GLP-1R agonists

June 13, 2025
Haisco Pharmaceutical Group Co. Ltd. has disclosed compounds acting as glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of diabetes and obesity.
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Red blood cells, artery
Endocrine/metabolic

Combining piperine and BCTC into a single drug to treat hyperuricemia

June 13, 2025
No Comments
In gout, excessive levels of uric acid in the blood lead to deposition of urate crystals in joints, which can cause strong inflammatory pain. Effectively treating gout involves mitigating not only the pain due to inflammatory responses, but also reducing uric acid levels in the blood, such as by inhibiting the uric acid transporter URAT1.
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Overweight man sitting on bed facing the window
Endocrine/metabolic

A CD47-blocking antibody ameliorates obesity and enhances exercise capacity

June 11, 2025
No Comments
Obesity is a major public health concern, and effective treatments are still elusive. AMP-activated protein kinase (AMPK) is a crucial regulator of energy homeostasis and has been proposed as a target for metabolic diseases, including obesity. However, most available AMPK agonists target multiple tissues to activate AMPK, which can cause adverse effects.
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