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Home » Topics » Disease categories and therapies » Gastrointestinal

Gastrointestinal
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Gastrointestinal

Imhotex identifies new NOD2 activators for treatment of Crohn’s disease

Nov. 19, 2024
Several recent Imhotex Ltd. patents describe novel analogues of muramyl dipeptide (MDP), desmuramylpeptides (DMPs), acting as nucleotide-binding oligomerization domain-containing protein 2 (NOD2) activators potentially useful for the treatment of Crohn’s disease.
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Endoflip system with display and catheter

​Medtronic receives CE mark for next generation Endoflip system​

Nov. 15, 2024
By Shani Alexander
Medtronic plc obtained a CE mark for its next generation Endoflip 300 system which measures pressure and dimensions in the esophagus and pylorus, in adults. The Endoflip can be used to help diagnose and treat thousands of people across Europe suffering with esophageal motility disorders.
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Gastrointestinal

Evotec International divulges new LPAM-1 antagonists

Nov. 15, 2024
Evotec International GmbH has synthesized integrin α4β7 (LPAM-1) antagonists reported to be useful for the treatment of ulcerative colitis and Crohn’s disease.
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Intestine
Gastrointestinal

Numab and Kaken Pharmaceutical sign agreement for ND-081 for inflammatory bowel disease

Nov. 15, 2024
Numab Therapeutics AG and Kaken Pharmaceutical Co. Ltd. have signed a new collaboration and option agreement to develop ND-081, a multispecific antibody for the treatment of inflammatory bowel disease.
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Illustration of gut bacteria on scales being evaluated by AI chip
Gastrointestinal

Machine learning links microbiome composition to bacterial load

Nov. 15, 2024
By Mar de Miguel
Many studies have linked the presence of specific bacteria to various diseases. But a general overgrowth of gut bacteria can be a symptom of different conditions, including colorectal cancer and inflammatory bowel disease. A study counting gut microbiome proposes that microbial load, rather than the disease, could explain the presence of certain pathogens.
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Art concept for drug research
Inflammatory

Series B financing at Trex Bio supports immunology pipeline development

Nov. 14, 2024
Trex Bio Inc. has closed an oversubscribed $84 million series B financing round to support development of its pipeline of novel therapies that modulate the immune system to restore human tissue immune homeostasis.
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Gastrointestinal

China Hinye Pharmaceutical describes new H+/K+-ATPase inhibitors

Nov. 13, 2024
China Hinye Pharmaceutical Co. Ltd. has identified pyrrole sulfonyl compounds and deuterated derivatives acting as H+/K+-ATPase inhibitors reported to be useful for the treatment of peptic ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease, dyspepsia, reflux esophagitis, Barrett esophagus, Helicobacter pylori infection and gastric cancer.
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Liver disease

Enterobiotix’s oral microbiota shows promise in liver cirrhosis

Nov. 11, 2024
By Nuala Moran
Microbiome specialist Enterobiotix Ltd. has reported positive results for the phase Ib trial of its EBX-102 fecal microbiota therapy in patients with stable liver cirrhosis. The placebo-controlled study involved first-in-human dosing with the company’s encapsulated oral formulation of microbiota derived from the stools of healthy donors. After initial dosing, patients were followed up for 12 weeks to assess changes in a range of clinical and blood biomarkers.
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3D illustration of human digestive system

OSE’s IL-7 therapy hits mark in ulcerative colitis trial

Nov. 5, 2024
By Nuala Moran
OSE Therapeutics SA has reported positive data for lusvertikimab in a phase II trial in ulcerative colitis, boosting the monoclonal antibody’s prospects of becoming the first anti-interleukin-7 therapy to reach the market.
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Illustration for inflammatory bowel disease
Gastrointestinal

Werewolf Therapeutics announces IL-10 Indukine development candidate for inflammatory bowel disease

Nov. 4, 2024
Werewolf Therapeutics Inc. has expanded its pipeline with the addition of a novel IL-10 Indukine development candidate, WTX-921, for inflammatory bowel disease (IBD) and potentially other inflammatory diseases.
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