Research led by Columbia University investigators has shed light on the immune pathway of the intestinal damage caused in celiac disease after gluten consumption. As reported in the July 14, 2023, issue of Science Immunology, the investigators showed an important role for cytotoxic T cells in addition to gluten-specific CD4+ T cells in the onset of celiac disease symptoms in a range of people with the condition.

A new study on the interleukin 1 (IL-1) pathway and its involvement in systemic inflammation and autoinflammatory diseases has described a mutation of the IL-1 receptor type 1 (IL-1R1) receptor associated with chronic recurrent multifocal osteomyelitis (CRMO). The variant p.Lys131Glu of this receptor was identified in a patient with CRMO. A peripheral blood mononuclear cell analysis showed an inflammatory event in lymphocytes, especially in monocytes and neutrophils. The research was conducted by a group of scientists at Zhejiang University in China and reported in the July 11, 2023, issue of Immunity.

After CAR T-cell immunotherapy for leukemia, some children have a longer remission because the engineered cells remain active and control or prevent the growth of new tumor cells. A new collaborative study has found that these persistent cells expressed certain genes that could be identified through a transcriptional signature. The finding could explain why the treatment does not work in some patients, and potentially help to improve it, reducing relapses.

In brain research, be it basic or clinical, neurons have long hogged the limelight. But at the 2023 European Meeting on Glial Cells in Health and Disease, neurons take a back seat to glia – cell types that have often been described as support cells and treated as an afterthought, but that play critical roles in all aspects of brain function, including information processing.

Researchers from Ermium Therapeutics SAS have presented preclinical data for the novel chemokine CXCR4 receptor ligand ER-000145, being developed for the treatment of type 1 interferonopathies, such as systemic lupus erythematosus (SLE).

Interleukin-17 (IL-17), a cytokine produced by T helper 17 (Th17) cells, is a key player in host inflammation and immune dysfunction leading to autoimmune diseases such as psoriasis, rheumatoid arthritis, multiple sclerosis or asthma, among others.

Blue Water Biotech Inc. has released preliminary preclinical data supporting the use of its norovirus shell and protrusion (S&P) virus-like particle (VLP) platform to develop a novel mpox vaccine candidate.