Arcus Biosciences Inc. has announced five new research programs for autoimmune and inflammatory diseases, and is targeting initiation of the first clinical studies next year.
Impaired fracture healing is a clinical management challenge. Fracture healing can be impaired due to several factors, such as aging, chronic inflammation or metabolic abnormalities. Osteoclasts play a crucial role in bone tissue reconstruction, but their abnormal activation can lead to impaired fracture healing. In a recent publication in Frontiers in Immunology, researchers from Naval Military Medical University and collaborators searched for crucial regulatory genes in the process of bone fracture healing.
At the American Society for Bone and Mineral Research (ASBMR) in Seattle, researchers from Ashibio Inc. reported preclinical efficacy data on vantictumab, a human monoclonal IgG2 lambda antibody that binds to multiple frizzled (FZD) receptors.
Heme oxygenase 1 (HO-1) is a stress-inducible enzyme that plays a critical role in the pathogenesis of rheumatoid arthritis, a systemic autoimmune disease characterized by chronic synovial inflammation, immune cell infiltration and progressive joint destruction.
Onco3r Therapeutics BV has obtained clinical trial application (CTA) approval by the Belgian regulatory authorities for its SIK3 inhibitor O3R-5671. A first-in-human trial will be conducted in Belgium and is expected to open enrollment in the coming weeks. Final data are expected in the first half of next year and will inform subsequent patient trials across a range of autoimmune diseases, which are planned to commence next year.
Researchers have identified a potential therapeutic target for muscular dystrophies, a group of genetic disorders characterized by progressive muscle weakness and degeneration. The study reveals that inhibiting the microRNA (miRNA) known as miRNA-33 can significantly improve muscle regeneration and ameliorate the dystrophic phenotype in animal models.
Osteoarthritis arises from breakdown of cartilage covering bone joints, which leads to chronic inflammation, and current therapies provide only short-term relief with risk of side effects. In an effort to identify next-generation treatments, researchers at Chang Gung University and Chang Gung Memorial Hospital have identified a potential novel therapeutic target, platelet-derived growth factor receptor-like protein (PDGFRL).
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the formation of an invasive and proliferative tissue called synovial pannus, consisting of fibroblast-like synoviocytes (FLSs), immune cells and newly formed vessels.
Homeobox genes, a conserved family of transcription factors, are key regulators of embryogenesis, cell growth and differentiation, and have been linked to bone mass regulation and osteogenesis. However, their specific roles in postmenopausal osteoporosis and osteoclast development are still not well understood, with limited and fragmented knowledge on which genes are central to these processes.
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