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Home » Topics » Disease categories and therapies » Ocular

Ocular
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Gold dollar sign

Series B brings Splicebio $135M for Stargardt disease asset

June 11, 2025
By Nuala Moran
No Comments
Three months after dosing the first patient with its dual vector gene therapy, Splicebio SL has closed a $135 million series B to fund the phase I/II trial of SB-007 in the treatment of Stargardt’s disease to completion. Other adeno-associated viru gene therapies for the inherited retinal disorder have entered the clinic, but SB-007 is the first with the capacity to deliver a full version of the ABCA4 gene that underlies Stargardt’s.
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Ocular

Roche identifies MMP-9 inhibitors for dry eye

June 10, 2025
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have patented 5-[2,7-diazaspiro[3.5]nonan-7-yl]-5-[4-phenoxyphenyl]hexahydropyrimidine-2,4,6-trione derivatives acting as matrix metalloproteinase-9, (MMP-9) inhibitors potentially useful for the treatment of dry eye.
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Eye wireframe illustration
Ocular

Chinese IND clearance for anti-IGF-1R antibody NTB-003 for thyroid eye disease

June 5, 2025
No Comments
Biocytogen Pharmaceuticals (Beijing) Co. Ltd. and Nanjing Chia Tai Tianqing Pharmaceutical Co. Ltd. have announced IND clearance by China’s National Medical Products Administration (NMPA) for NTB-003 (formerly BCG-009) for thyroid eye disease.
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Ocular

New CB1 and CB2 receptor modulators disclosed in Inmed patent

May 30, 2025
Inmed Pharmaceuticals Inc. has divulged cannabinoid CB1 and/or CB2 receptor modulators reported to be useful for the treatment of neurodegeneration and age-related macular degeneration.
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Ocular

AAV8-RK-hBBS10 gene therapy restores vision in Bardet-Biedl syndrome type 10 model

May 29, 2025
No Comments
Bardet-Biedl syndrome (BBS) is a group of rare autosomal recessive ciliopathies characterized by dysfunction of primary cilia, which affects multiple organ systems and leads to early-onset obesity, progressive retinal degeneration resulting in vision loss or blindness, and renal abnormalities that may progress to renal failure. Mutations in the BBS10 gene are the second most prevalent cause of BBS, accounting for over 20% of cases.
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Ocular

BMP4 inhibition offers dual benefit in AMD: antifibrotic and antineovascularization effects

May 20, 2025
No Comments
Age-related macular degeneration (AMD) is the primary cause of blindness in people aged 65 and older in developed nations. Recent estimates suggest that, globally, the number of individuals affected by AMD could rise to approximately 288 million by 2040.
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Ocular

Neuroplastin 65 knockout disrupts visual function by altering the retina

May 14, 2025
No Comments
Researchers from Tongji University School of Medicine and collaborating institutions have discovered that NP65 plays a crucial role in maintaining normal visual function in mice. The study, published in Frontiers in Cellular Neuroscience, found that mice lacking NP65 exhibit impaired visual responses.
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Ocular

CTX-114 enhances surface binding and function of complement factor H

May 13, 2025
No Comments
Among the most significant genetic risk factors for age-related macular degeneration is the Y402H variant of complement factor H, which, along with its splice isoform FHL-1, impairs binding to the retinal surface.
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Close up of woman's bulging eyes
Ocular

Identifying NNMT as a therapeutic target in an autoimmune eye disorder

May 9, 2025
No Comments
Individuals with autoimmune diseases affecting the thyroid can suffer eye complications in the form of Graves’ orbitopathy, in which inflammation in and around the orbit leads to eyelid retraction, eye bulging and other symptoms.
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Illustration of human eye
Ocular

SBT-272 confers neuroprotection in experimental glaucoma

May 9, 2025
No Comments
The progression of neurodegeneration during experimental glaucoma is tied to the early degradation of anterograde transport along retinal ganglion cells to central brain targets, which is followed by frank optic nerve degeneration.
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