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Home » Topics » Disease categories and therapies » Ocular

Ocular
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Close up of eye and vision test

Eylea down and slept? Regeneron keeps faith in AMD biosimilar war

Nov. 1, 2024
By Randy Osborne
The nearer-looming threat of a biosimilar from Amgen Inc. to heavyweight Regeneron Pharmaceuticals Inc.’s age-related macular degeneration (AMD) VEGF therapy, Eylea (aflibercept), along with other issues, pressured shares of the latter (NASDAQ:REGN) since reporting third-quarter earnings Oct 31. But Wall Street pundits are not altogether aligned on how serious the scenario might be. After the earnings update, Regeneron’s stock fell 12%, from $925 to $819.96, and closed Nov. 1 at $843.60, up $5.40.
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Qself eye exam
Patents

Eyecheq files for protection of self-service retinal image kiosks

Oct. 31, 2024
By Simon Kerton
In what represents the first patenting from Eyecheq Inc., the company is seeking protection for its self-guided eye examination systems which may be mounted in easily movable and transportable kiosks, on tabletop stands, walls or suspended from ceilings.
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Astellas withdraws its EU MAA for geographic atrophy

Oct. 29, 2024
By Tamra Sami
Astellas Pharma Inc. has withdrawn its marketing authorization application from the EMA for its avacincaptad pegol intravitreal solution for the treatment of geographic atrophy secondary to age-related macular degeneration. “The company's decision to withdraw its application followed interactions” with the EMA’s Committee for Medicinal Products for Human Use, an Astellas spokesperson told BioWorld.
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Eye wireframe illustration
Ocular

QM-107, a novel therapeutic peptide for the treatment of neovascular eye diseases

Oct. 25, 2024
Syndecan-2 can inhibit angiogenesis through its interaction with the protein tyrosine phosphatase receptor CD148 (RTP type J).
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DNA illustration
Ocular

AAV8-RK-hBBS10 increases retinal function and thickness in mouse model of Bardet-Biedl syndrome

Oct. 23, 2024
Mutations in the BBS10 gene are the second most common cause of Bardet-Biedl syndrome (BBS). Researchers from Meiragtx Ltd. aimed to optimize and identify an AAV vector carrying the human (h)BBS10 gene, obtaining sustained efficacy as well as good safety for clinical translation for the treatment of BBS.
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Woman using eyedrops
Ocular

Grifols partners with BARDA to test ocular immunoglobulin for sulfur mustard-induced eye damage

Oct. 23, 2024
Grifols SA has entered into a partnership with the U.S. Biomedical Advanced Research and Development Authority (BARDA) to test investigational ocular surface immunoglobulin (OSIG) eye drops for their ability to treat ocular damage from sulfur mustard exposure.
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Ocular

Shanghai Meiyue Biotech Development divulges new complement factor B inhibitors

Oct. 18, 2024
Shanghai Meiyue Biotech Development Co. Ltd. has synthesized spiro compounds acting as complement factor B (CFB) inhibitors reported to be useful for the treatment of age-related macular degeneration, glomerulonephritis, atypical hemolytic uremic syndrome, membranous nephropathy, myasthenia gravis, paroxysmal nocturnal hemoglobinuria, diabetic retinopathy and rheumatoid arthritis, among others.
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Man with eye disorder
Ocular

New study reveals druggable target for cataract treatment

Oct. 14, 2024
Protein homeostasis is disrupted in response to an uncontrolled stress condition, a hallmark of many diseases, such as cataracts. Lens protein accumulation and aggregates are a cause of cataract development.
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Adult fly brain 3D reconstruction
Neurology/psychiatric

140,000 cells and 50M synapses make 1 adult fly brain

Oct. 3, 2024
By Mar de Miguel
A collaboration led by the Flywire Consortium and comprising hundreds of scientists has completed a whole map of the adult fruit fly brain after several decades of collaborative work.
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Adult fly brain 3D reconstruction
Neurology/psychiatric

140,000 cells and 50M synapses make 1 adult fly brain

Oct. 2, 2024
By Mar de Miguel
A collaboration led by the Flywire Consortium and comprising hundreds of scientists has completed a whole map of the adult fruit fly brain after several decades of collaborative work. By using electron microscopy and three-dimensional reconstruction supported by AI tools, the researchers have revealed the neural wiring of the Drosophila melanogaster brain, a connectome of 140,000 neurons with 50 million synaptic connections. In the future, researchers could possibly use this map as an artificial in silico model to study the brain as a simulator through its connections, though a lot of work remains to be done for this.
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