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Home » Topics » Disease categories and therapies » Ocular

Ocular
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Infection

GL-287 and GL-382 inhibit Zika virus replication in ocular cells, study shows

Sep. 4, 2024
In the search for more potent, safe and effective autophagy inhibitor compounds, researchers from the Wayne State University School of Medicine have developed novel piperazine- and piperidine-substituted quinoline derivatives GL-287 and GL-382, based on the quinoline scaffold of hydroxychloroquine.
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Eye and DNA illustration
Ocular

CRISPR/Cas9-mediated gene editing therapy shows efficacy in latent rabbit model of HSV-1 keratitis

Aug. 28, 2024
Researchers from Excision Biotherapeutics Inc. and affiliated organizations have reported the development of a novel CRISPR/Cas9-mediated genome editing therapy – EBT-104 – for the treatment of latent herpes simplex virus 1 (HSV-1) keratitis.
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Eye exam
Ocular

Find Therapeutics’ remyelinating agent gains IND clearance for chronic optic neuropathy

Aug. 28, 2024
Find Therapeutics Inc. has obtained FDA clearance of its IND application for FTX-101, a first-in-class remyelinating agent that aims to restore vision in people with chronic optic neuropathy.
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Fundus image of eye with age-related macular degeneration.
Ocular

Innovec’s IVB-103 gains US IND clearance for neovascular AMD

Aug. 19, 2024
Innovec Pharmaceutical Technology Co. Ltd. (Innovec Biotherapeutics) has received FDA clearance for its IND application for IVB-103, an AAV-based gene therapy for neovascular age-related macular degeneration (AMD).
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Aldeyra perseveres in phase III of dry eye disease

Aug. 9, 2024
By Lee Landenberger
Aldeyra Therapeutics Inc. has bounced back from a complete response letter in November to produce positive phase III data for reproxalap in treating dry eye disease. The company is one of many developing treatments using diverse mechanisms of action.
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Ocular

Kodiak Sciences identifies NLRP3 inflammasome inhibitors for eye diseases

July 31, 2024
Kodiak Sciences Inc. has described NLRP3 inflammasome inhibitors reported to be useful for the treatment of age-related macular degeneration, choroidal neovascularization, diabetic macular edema, dry eye, glaucoma, bacterial keratitis, retinitis and uveitis, among others.
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Diagram showing parts of the eye
Ocular

Exopten aids optic nerve recovery in rats

July 19, 2024
Nurexone Biologic Inc. has announced preliminary results from a small-scale controlled study at Sheba Medical Center exploring the use of nanodrug Exopten for optic nerve recovery in a rat model. An optic nerve crush (ONC) model was used to simulate conditions such as glaucoma, where the optic nerve is damaged, resulting in impaired vision.
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Optogenetics illustration

4D, Adverum phase IIs inflame AMD gene therapy space

July 17, 2024
By Randy Osborne
As the hunt goes on for a better treatment in wet age-related macular degeneration (AMD), landmark analyses of two batches of phase II gene therapy data billed as positive were disclosed during the American Society of Retina Specialists annual meeting in Stockholm, where 4D Molecular Therapeutics Inc. and Adverum Biotechnologies Inc. offered findings.
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Addnox migraine device by Nu Eyne

Nu Eyne advances bioelectric wearables beyond migraine, ADHD

July 17, 2024
By Marian (YoonJee) Chu
Beyond its success in migraine and attention deficit hyperactivity disorder, Nu Eyne Co. Ltd. is advancing a portfolio of noninvasive, wearable trigeminal nerve stimulation devices across key three areas of neuromodulation, tissue regeneration and proliferation inhibition.
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Illustration of the inside of an eye with macular degeneration
Ocular

Nexthera files IND application for NT-101 eye drop for wet AMD

July 17, 2024
Nexthera Co. Ltd. has submitted an IND application to the FDA seeking to conduct a phase I/IIa trial with NT-101, a noninvasive eye drop treatment for wet age-related macular degeneration (AMD).
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