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Home » Topics » Disease categories and therapies » Ocular

Ocular
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Ocular

EGR2 protects the eye from uveitis by impacting GDF15 signaling

Sep. 26, 2024
Uveitis is a disease involving the eye, affecting the iris, ciliary body, retina and their associated blood vessels, among others. The non-infectious type of uveitis is linked to immune-related factors and its pathogenesis remains poorly understood.
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Illustration demonstrating structure of the human eye and organization of retinal cells
Ocular

Boehringer Ingelheim to advance SZN-413 for retinal diseases

Sep. 25, 2024
Surrozen Inc. has announced that Boehringer Ingelheim Pharma GmbH & Co. KG will further develop SZN-413 to advance the compound and prepare it for clinical testing. Boehringer decided to move forward with development based on the completion of the initial period of joint research under the companies’ strategic partnership for the research and development of SZN-413 for the treatment of retinal diseases.
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EMA’s CHMP recommends Hympavzi for hemophilia, Elahere for cancer

Sep. 23, 2024
By Nuala Moran
For once, the EMA appears to have pipped the U.S. FDA to the post, with Pfizer Inc.’s hemophilia A and B therapy Hympavzi (marstacimab) recommended for approval in Europe on Sept. 20, while the U.S. PDUFA date is set for the fourth quarter of the year.
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Close-up of eye with digital focus
Ocular

Glaukos signs agreement for Nicox’s NO-donating PDE5 inhibitor for eye indications

Sep. 23, 2024
Nicox SA has entered into an exclusive research and license option agreement with Glaukos Corp. for NCX-1728, Nicox’s novel nitric oxide (NO)-donating phosphodiesterase PDE5 inhibitor.
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Profile view of the human head highlighting the eye
Ocular

Partial epigenetic reprogramming to treat ischemic optic neuropathy

Sep. 12, 2024
By Mar de Miguel
A novel gene therapy that leads to cellular rejuvenation could restore vision after non-arteritic anterior ischemic optic neuropathy (NAION) and glaucoma. The technique is based on a reprogramming process that reverses the epigenetic DNA alterations caused by aging. Preclinical studies in glaucoma mice and nonhuman primates (NHP) models for this stroke-like disorder that affects the eye, showed an improvement of vision and restoration of the damaged axons of the optic nerve.
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Close up of man's eye

Viridian Thrives on phase III with veligrotug in thyroid eye

Sep. 10, 2024
By Randy Osborne
Implications for Amgen Inc.’s same-class Tepezza (teprotumumab) of positive phase III data from Viridian Therapeutics Inc. with veligrotug in thyroid eye disease became a topic of talk on Wall Street talk. “I’m not drawing any clinical trial comparisons, you’ll have to reach your own conclusions,” CEO Steve Mahoney said during a conference call on the results.
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Ocular

Development and characterization of a new environmental myopia zebrafish model

Sep. 6, 2024
Researchers from The University of Melbourne published data from a study that aimed to establish a novel myopia model that would facilitate large-scale in vivo studies for investigating molecular signaling and gene-environment interactions in myopia development.
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Ocular

Merck Sharp & Dohme describes new KLKB1 Inhibitors

Sep. 5, 2024
Merck Sharp & Dohme LLC has identified plasma kallikrein (KLKB1) Inhibitors reported to be useful for the treatment of diabetic retinopathy, retinal vein occlusion, hereditary angioedema, diabetes, pancreatitis, intracerebral hemorrhage, nephropathy and inflammatory disorders.
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Illustration of human eye
Ocular

Skyline Therapeutics’ gene therapy awarded US orphan drug designation for retinitis pigmentosa

Sep. 4, 2024
Skyline Therapeutics (Shanghai) Co. Ltd.’s SKG-1108, a novel one-time intravitreally delivered gene therapy, has been awarded U.S. orphan drug designation for the treatment of retinitis pigmentosa.
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Infection

GL-287 and GL-382 inhibit Zika virus replication in ocular cells, study shows

Sep. 4, 2024
In the search for more potent, safe and effective autophagy inhibitor compounds, researchers from the Wayne State University School of Medicine have developed novel piperazine- and piperidine-substituted quinoline derivatives GL-287 and GL-382, based on the quinoline scaffold of hydroxychloroquine.
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