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BioWorld - Wednesday, June 11, 2025
Home » Topics » Disease categories and therapies » Ocular

Ocular
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Ocular

Sitala Bio patents describe complement factor B inhibitors

Jan. 28, 2025
Sitala Bio Ltd. has prepared new indole derivatives acting as complement factor B (CFB) inhibitors. They are thus reported to be useful for the treatment of age-related macular degeneration, schizophrenia, atypical hemolytic uremic syndrome, membranous nephropathy, myasthenia gravis, paroxysmal nocturnal hemoglobinuria, diabetic retinopathy and rheumatoid arthritis, among others.
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Eye and DNA illustration
Neurology/psychiatric

Tikun programs receive orphan, rare pediatric disease designations

Jan. 23, 2025
Tikun Therapeutics Inc. has obtained U.S. orphan drug and rare pediatric disease designations for its programs in familial dysautonomia, namely its rAAV2-U1a-hELP1 gene replacement therapy for the treatment of optic neuropathy in familial dysautonomia and BPN-36964 for systemic treatment of familial dysautonomia.
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Illustration demonstrating structure of the human eye and organization of retinal cells
Ocular

miR-429 protects eye from photoreceptor degeneration, study finds

Jan. 22, 2025
Inherited retinal diseases (IRDs) are a group of monogenic disorders caused by mutations in more than 280 genes, and are characterized by progressive degeneration of photoreceptor cells in the retina.
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Ocular

Gemvax & Kael describes new peptides for AMD, cerebral amyloid angiopathy and Alzheimer’s

Jan. 21, 2025
Gemvax & Kael Co. Ltd. has identified peptides reported to be useful for the treatment of age-related macular degeneration (AMD), cerebral amyloid angiopathy and Alzheimer’s disease.
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Eye illustration
Ocular

CREB inhibitor successfully prevents corneal neovascularization

Jan. 17, 2025
Corneal neovascularization (CNV) occurs when abnormal blood vessels grow into the cornea in response to ischemic or hypoxic conditions caused by infections, inflammation or chemical injuries.
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Eye with digital overlay

JPM: Sling’s small molecule has success in thyroid eye disease

Jan. 14, 2025
By Lee Landenberger
Day two of the J.P Morgan Healthcare Conference rolled on with positive data from Sling Therapeutics Inc. that is leading the company to a phase III study in treating thyroid eye disease. The privately held company posted top-line efficacy and safety results from a phase IIb/III study of its lead candidate, linsitinib, which hits its primary endpoint with statistical significance at the twice-daily, 150-mg oral dose.
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Close-up of elderly eye
Ocular

Pulsesight seeks clinical trial clearance for PST-611 for dry AMD/geographic atrophy

Jan. 14, 2025
Pulsesight Therapeutics SAS has submitted a clinical trial authorization (CTA) to the French authority ANSM seeking to conduct a first-in-human phase I trial of PST-611 for dry age-related macular degeneration (AMD)/geographic atrophy (GA).
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Drug capsule spilling onto brain
Neurology/psychiatric

Tenvie Therapeutics launches with focus on neurological diseases

Jan. 9, 2025
The company is advancing a pipeline of therapeutics, including programs acquired from Denali Therapeutics Inc., focused on treating neurological, cardiometabolic and ophthalmic diseases.
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US FDA weighs in on timing of confirmatory trials

Jan. 7, 2025
By Mari Serebrov
What does it mean for a confirmatory trial to be “underway”? That’s a question that’s been plaguing some drug sponsors, especially those in the ultra-rare disease space, since the U.S. Congress, in 2023, gave the FDA the authority to require that a confirmatory trial be underway at the time accelerated approval is granted.
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Diagram showing parts of the eye
Ocular

Novel chalcone derivative ameliorates optic nerve injuries

Jan. 7, 2025
Proper survival and regeneration of retinal ganglion cells (RGCs), which constitute the optic nerve, is crucial for managing traumatic or ischemic optic nerve injury, optic neuropathy, or optic pathway gliomas. Researchers from Wenzhou Medical University described the synthesis of novel spirocyclic chalcone derivatives designed to combat optic nerve damage.
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