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BioWorld - Friday, May 23, 2025
Home » Topics » Ocular, BioWorld Science

Ocular, BioWorld Science
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Ocular

BMP4 inhibition offers dual benefit in AMD: antifibrotic and antineovascularization effects

May 20, 2025
No Comments
Age-related macular degeneration (AMD) is the primary cause of blindness in people aged 65 and older in developed nations. Recent estimates suggest that, globally, the number of individuals affected by AMD could rise to approximately 288 million by 2040.
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Ocular

Neuroplastin 65 knockout disrupts visual function by altering the retina

May 14, 2025
No Comments
Researchers from Tongji University School of Medicine and collaborating institutions have discovered that NP65 plays a crucial role in maintaining normal visual function in mice. The study, published in Frontiers in Cellular Neuroscience, found that mice lacking NP65 exhibit impaired visual responses.
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Ocular

CTX-114 enhances surface binding and function of complement factor H

May 13, 2025
No Comments
Among the most significant genetic risk factors for age-related macular degeneration is the Y402H variant of complement factor H, which, along with its splice isoform FHL-1, impairs binding to the retinal surface.
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Close up of woman's bulging eyes
Ocular

Identifying NNMT as a therapeutic target in an autoimmune eye disorder

May 9, 2025
No Comments
Individuals with autoimmune diseases affecting the thyroid can suffer eye complications in the form of Graves’ orbitopathy, in which inflammation in and around the orbit leads to eyelid retraction, eye bulging and other symptoms.
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Illustration of human eye
Ocular

SBT-272 confers neuroprotection in experimental glaucoma

May 9, 2025
No Comments
The progression of neurodegeneration during experimental glaucoma is tied to the early degradation of anterograde transport along retinal ganglion cells to central brain targets, which is followed by frank optic nerve degeneration.
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Ocular

ABI-201 confers protection against age-related macular degeneration

May 8, 2025
No Comments
ABI-201 is an engineered AAV.N54 vector that expresses a soluble CD59 variant and a complement 3 (C3) inhibitor fusion protein. ABI-201 was developed by Avirmax Biopharma Inc. to confer photoreceptor protection against retinal damage. The effects of ABI-201 were tested in a sodium iodate-induced retinal damage model in nonhuman primates, a widely used model for testing therapies for age-related macular degeneration (AMD).
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Drug R&D concept image.
Ocular

Surrozen’s SZN-8141 ameliorates retinopathy in murine models

May 7, 2025
No Comments
Recent evidence has suggested that the use of norrin mimetics targeting both frizzled-4 (FZD4) and low-density lipoprotein receptor-related protein 5 (LRP5) may be highly effective at modulating retinal vascular leakage. When combined with an anti-VEGF therapy, it was hypothesized to have an additive benefit potential for treating retinal vascular disorders.
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Ocular

PBI-671 induces retinal ganglion cell survival in glaucoma models

May 7, 2025
No Comments
Glaucoma is a leading cause of blindness and is characterized by the death of retinal ganglion cells (RGCs). Genetic screening data have identified dual leucine zipper kinase (DLK) and leucine zipper kinase (LZK) as important mediators of RGC death.
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Eye wireframe illustration
Ocular

Odylia announces new program in NPHP1-associated retinal dystrophy

May 6, 2025
No Comments
Odylia Therapeutics Inc. has announced it is working under a codevelopment partnership with the NPHP1 Family Foundation to create an AAV-based gene replacement therapy for retinal dystrophy caused by mutations in the NPHP1 (nephrocystin-1) gene.
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Colorful illustration of reconstructed brain cells
Neurology/psychiatric

Mouse brain structure and function shown on high-resolution map

April 11, 2025
By Mar de Miguel
Scientists from the Machine Intelligence from Cortical Networks (MICRONS) consortium have published the microconnectome of a cubic millimeter of the mouse brain. This is the most complete map of this organ to date at nanometer resolution for a mammal. It not only contains the structure and connections of each and every cell in that volume of tissue, but is also linked to the neuronal activity of that portion of the CNS, linking anatomy and function in the same cells.
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