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BioWorld - Thursday, May 28, 2026
Home » Topics » Disease categories and therapies » Ocular

Ocular
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Ocular

Soluble Fas ligand prevents disease progression in glaucoma model

May 6, 2024
Schepens Eye Research Institute presented new preclinical data on its AAV2.sFasL gene therapy, an adeno-associated virus (AVV2) encoding soluble Fas ligand (sFasL) for the potential prevention of glaucoma.
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Ocular

FDA accepts IND for Eluminex’s EB-105

May 2, 2024
Eluminex Biosciences Ltd. announced the FDA’s acceptance of their IND application for EB-105, a trispecific fusion antibody targeting vascular endothelial growth factor A (VEGF-A, and isomers), VEGF-B, placental growth factor (PlGF), angiopoietin-2 (Ang-2) and interleukin-6 receptor (IL-6R) for the treatment of diabetic macular edema (DME).
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Ocular

cGAS inhibitors described in Bellbrook Labs patent

April 30, 2024
Work at Bellbrook Labs LLC has led to the discovery of imidazolyl-alkoxyquinolin-2-amines acting as cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors.
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Dollar sign in piggy bank
Ocular

Revopsis raises funding to advance lead nAMD candidate

April 26, 2024
Revopsis Therapeutics Inc. has closed its first seed funding round, raising $16.5 million that will fund the completion of ongoing IND-enabling studies with its lead candidate, RO-104, for the treatment of neovascular age-related macular degeneration (nAMD). Developed using the company’s proprietary Rev-Mod platform, RO-104 is a potentially first-in-class fully human modular trispecific biologic.
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Medical vector illustration showing cross section of an eyeball with close up of the macula
Ocular

Saliogen nominates development candidate for Stargardt disease

April 18, 2024
Saliogen Therapeutics Inc. has nominated a development candidate, SGT-1001, for the treatment of Stargardt disease. SGT-1001 is being developed as a one-time, nonviral therapy to slow or stop the progressive loss of central vision in people with Stargardt disease, regardless of the type of mutation.
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Illustration of the inside of an eye with macular degeneration
Ocular

Inmed’s INM-089 shows functional and pathological improvements in in vivo AMD models

April 17, 2024
Inmed Pharmaceuticals Inc. has released new preclinical data on INM-089 further demonstrating promising pharmacological effects targeting dry age-related macular degeneration (AMD). INM-089 is a proprietary small-molecule compound acting as a preferential signaling ligand of cannabinoid CB1 and CB2 receptors.
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Induced pluripotent stem cells
Ocular

Series A readies Rxcell's iPSC-derived photoreceptors for clinic

April 16, 2024
By Tamra Sami
On the heels of a $4.6 million series A round in December 2023, cell therapy company Rxcell Inc. is planning to raise another $15 million in 2024 to take its iPSC-derived photoreceptors to the clinic for retinitis pigmentosa and other degenerative diseases of the retina.
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Induced pluripotent stem cells
Newco news

Series A readies Rxcell's iPSC-derived photoreceptors for clinic

April 16, 2024
By Tamra Sami
On the heels of a $4.6 million series A round in December 2023, cell therapy company Rxcell Inc. is planning to raise another $15 million in 2024 to take its iPSC-derived photoreceptors to the clinic for retinitis pigmentosa and other degenerative diseases of the retina.
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Regeneron hit with fraud claims for credit card subsidies

April 11, 2024
By Mari Serebrov
With credit card fees taking a sizable bite of their billings, many U.S. health care providers are fighting back by offering patients cash discounts. But when a drug company covers card processing fees for its distributors to pass on to their provider clients so they can pay for so-called “buy-and-bill” Medicare Part B drugs with a credit card at cash prices, it’s fraud if those concessions aren’t figured into the drug’s average sales price – at least that’s what the U.S. Department of Justice is claiming in a complaint it released April 10 against Regeneron Pharmaceuticals Inc.
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Induced pluripotent stem cells
Newco news

Series A readies Rxcell's iPSC-derived photoreceptors for clinic

April 10, 2024
By Tamra Sami
On the heels of a $4.6 million series A round in December 2023, cell therapy company Rxcell Inc. is planning to raise another $15 million in 2024 to take its iPSC-derived photoreceptors to the clinic for retinitis pigmentosa and other degenerative diseases of the retina.
Read More
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