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BioWorld - Monday, March 27, 2023
Home » Topics » Respiratory, BioWorld Science

Respiratory, BioWorld Science
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Respiratory

Roche discovers new PDK1 inhibitors

Dec. 15, 2022
No Comments
Roche has synthesized pyruvate dehydrogenase kinase 1 (PDK1) inhibitors reported to be useful for the treatment of systemic lupus erythematosus, psoriasis, inflammatory bowel diseases, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and cancer.
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Respiratory

Vertex cleared to enter clinic with mRNA therapy VX-522 for cystic fibrosis

Dec. 13, 2022
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Vertex Pharmaceuticals Inc. has received clearance from the FDA for its IND application for VX-522, a messenger ribonucleic acid (mRNA) therapy targeted at treating the underlying cause of cystic fibrosis (CF).
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Lungs
Respiratory

Sionna advances NBD1 modulator SION-638 for cystic fibrosis

Dec. 9, 2022
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Sionna Therapeutics Inc. has received FDA clearance of its IND application for SION-638, a small molecule designed to target the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. A phase I study is now dosing healthy volunteers.
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Illustrations of nasal cavities comparing rhinitis to normal.
Respiratory

Hyloris developing intranasal TRPV1 agonist to treat idiopathic rhinitis

Nov. 23, 2022
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Hyloris Pharmaceuticals SA has announced the development of HY-083, a new proprietary intranasal formulation of a TRPV1 agonist to treat idiopathic rhinitis. Hyloris' treatment approach is to activate and depolarize TRPV1 receptors leading to restoration of a normal function of the nasal mucosa.
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Respiratory

Chinese researchers divulge new PDE3A and/or PDE4 inhibitors

Nov. 21, 2022
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Suzhou Suncadia Biopharmaceuticals Co. Ltd. and Jiangsu Hengrui Medicine Co. Ltd. have synthesized isoquinolone compounds acting as phosphodiesterase PDE3A and/or PDE4 inhibitors reported to be useful for the treatment of asthma, chronic obstructive pulmonary disease (COPD), sepsis, nephritis, diabetes, allergic rhinitis, allergic conjunctivitis and rheumatic diseases.
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Respiratory

Boehringer Ingelheim presents TRPA1 inhibitors for respiratory indications

Nov. 10, 2022
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Boehringer Ingelheim Pharma GmbH & Co. KG has divulged imidazo[4,5-d]pyridazinonyl derivatives acting as transient receptor potential cation channel subfamily A member 1 (TRPA1) antagonists reported to be useful for the treatment of cough, fibrosis, respiratory tract inflammation and idiopathic pulmonary fibrosis.
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Respiratory

Humanwell Healthcare patent details GPR84 antagonists

Nov. 10, 2022
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Humanwell Healthcare (Group) Co. Ltd. has synthesized dihydropyrimidoisoquinolinone derivatives acting as G protein-coupled receptor 84 (GPR84) antagonists reported to be useful for the treatment of chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, inflammatory bowel disease, pulmonary fibrosis, vasculitis, infections, metabolic and endocrine disorders, among others.
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Lungs
Respiratory

Tavanta Therapeutics reports in vitro data on TAVT-135 for cystic fibrosis

Nov. 7, 2022
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Modulators of cystic fibrosis transmembrane...
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Respiratory

Angion Biomedica describes new HGF mimetic compounds

Nov. 4, 2022
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Angion Biomedica Corp. has synthesized prodrugs of terevalefim acting as hepatocyte growth factor (HGF) mimetics and reported to be useful for the treatment of renal ischemia-reperfusion and lung injury.
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Intestine
Inflammatory

Saniona completes preclinical development of SAN-903 for inflammatory and fibrotic diseases

Nov. 4, 2022
No Comments
Saniona AB has completed preclinical development with SAN-903 and is ready to start the regulatory process for entering phase I trials either alone or together with a partner. SAN-903 is a novel, potential first-in-class medicine based on inhibition of the calcium-activated potassium ion channel KCa3.1.
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