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BioWorld - Sunday, July 20, 2025
Home » Topics » Respiratory, BioWorld Science

Respiratory, BioWorld Science
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Lungs
Respiratory

IBI-3002 exerts potent anti-inflammatory activity in preclinical asthma models

May 23, 2025
No Comments
Interleukin-4 receptor α (IL-4Rα), a shared receptor subunit for both IL-4 and IL-13, along with thymic stromal lymphopoietin (TSLP), are key drivers of the type 2 inflammatory cascade involved in asthma and other inflammatory disorders.
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Respiratory

New antagonists of cannabinoid CB1 receptor to alleviate allergic rhinitis

May 23, 2025
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Nearly half of the world’s population suffers from allergic rhinitis, meaning that when they inhale allergens from the air, IgE becomes activated and induces paroxysmal sneezing, runny nose and nasal itching. Several types of drugs are currently used to manage the condition, including antihistamines, corticosteroids and antagonists of the leukotriene receptor; but some are associated with side effects.
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Respiratory

New Nav1.7 channel blockers for cough disclosed in Chiesi patent

May 22, 2025
Chiesi Farmaceutici SpA has divulged sodium channel protein type 9 subunit α (Nav1.7) channel blockers reported to be useful for the treatment of chronic cough.
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Lungs
Respiratory

PERK inhibition reverses asbestos-induced pulmonary fibrosis in mice

May 22, 2025
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Pulmonary fibrosis is a lung disease with limited therapeutic options and the development of new therapeutics is a clinical unmet need. Little is known about the role of endoplasmic reticulum stress and unfolded protein response seen in macrophages during pulmonary fibrosis.
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Lungs
Respiratory

Astrazeneca’s AZD-6793 arises as a promising therapeutic for COPD

May 22, 2025
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Chronic obstructive pulmonary disease (COPD) is among the most leading causes of death around the world and there are insufficient treatment options that prevent exacerbations or alter the progression of the disease. COPD is a complex disease with multiple factors driving inflammation, emphysema or small airway remodeling, among others, where interleukin-1 receptor-associated kinase 4 (IRAK-4) plays a crucial role in the pathogenesis of the disease.
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Respiratory

KT-621: a first-in-class STAT6 degrader for Th2-driven diseases

May 22, 2025
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STAT6 plays a central role in regulating Th2-driven immune responses. Recent studies have identified gain-of-function mutations in the STAT6 gene that are associated with early-onset, severe allergic diseases. As a result, STAT6 has emerged as a promising therapeutic target in conditions such as asthma, eosinophilic inflammation, food allergies and atopic dermatitis, particularly in cases that are refractory to standard therapies.
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Respiratory

Zymeworks’ bispecific antibody relieves airway inflammation in asthma and COPD models

May 21, 2025
No Comments
Chronic obstructive pulmonary disease (COPD) is a prevalent and heterogeneous respiratory disorder with limited effective treatments. IL-33 and IL-4Rα are key mediators of airway inflammation in COPD and hence represent potential therapeutic targets.
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AI-generated image of illustration of MRI of lungs with fibrosis
Respiratory

Atyr begins IND-enabling studies with candidate for pulmonary fibrosis

May 15, 2025
No Comments
Atyr Pharma Inc. has advanced ATYR-0101 into IND-enabling studies for pulmonary fibrosis, and is targeting an IND application in the second half of next year.
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Digital lungs illustration
Respiratory

Next-generation inhibitor of the P2Y14 receptor to treat acute lung injury

May 14, 2025
No Comments
The metabotropic nucleotide receptor P2Y14 shows strong potential as a therapeutic target against various inflammatory diseases, particularly acute lung injury, yet the small-molecule inhibitors described so far have performed poorly in preclinical studies.
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Lung illustration
Respiratory

BLR Bio’s BLR-200 demonstrates antifibrotic effects in lung fibrosis model

May 2, 2025
No Comments
BLR Bio LLC has announced new data on BLR-200, its lead compound for systemic sclerosis and lung fibrosis. In the new study, BLR-200 demonstrated the ability to reduce key disease tissue markers for fibrotic lung disease.
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