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BioWorld - Saturday, July 19, 2025
Home » Topics » Respiratory, BioWorld Science

Respiratory, BioWorld Science
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Gastrointestinal

Equillium advancing new AhR modulator

May 2, 2025
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Equillium Inc. is advancing EQ-504, a potent aryl hydrocarbon receptor (AhR) modulator acquired through the acquisition of Ariagen Inc., a company that was majority owned by Equillium’s largest investor, Decheng Capital.
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Lungs
Respiratory

MARCKS protein is potential target in equine asthma model

April 23, 2025
A recent study in Respiratory Research further investigated the expression and role of the myristoylated alanine-rich C kinase substrate (MARCKS) protein in a horse model of asthma.
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Inflammatory

Aclaris gains IND clearance for bispecific anti-TSLP/IL-4R antibody

April 23, 2025
Aclaris Therapeutics Inc. has gained IND clearance from the FDA for ATI-052, a bispecific anti-thymic stromal lymphopoietin (TSLP)/interleukin-4 receptor (IL-4R) monoclonal antibody being developed to treat certain immuno-inflammatory diseases. A phase Ia/Ib trial, including a proof-of-concept portion in an undisclosed indication, will begin in the current quarter.
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Illustration of cell dividing
Cancer

Germline variants’ impact on pan-cancer proteome

April 22, 2025
By Mar de Miguel
A large-scale study has revealed the impact of germline variants on proteins in 10 cancer types. Scientists from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) conducted a precision proteogenomic analysis in a pan-cancer study with data from 1,064 patients, identifying tumor heterogeneity and tumorigenesis associated with heritable genetic alterations. The results provide a broad view of cancer risk that could be useful for patient stratification and the design of prevention strategies.
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Respiratory

New cathepsin C inhibitors disclosed in Insmed patent

April 16, 2025
Insmed Inc. has divulged cathepsin C (dipeptidyl peptidase I, DPP1) inhibitors reported to be useful for the treatment of amyotrophic lateral sclerosis, asthma, metastatic cancer, chronic rhinosinusitis, heart failure, inflammatory bowel disease, psoriasis and thrombosis, among others.
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Respiratory

Shanghai Yidi Biotechnology patents new ELANE inhibitors

April 11, 2025
Shanghai Yidi Biotechnology Co. Ltd. has disclosed neutrophil elastase (ELANE; leukocyte elastase) inhibitors reported to be useful for the treatment of pain and respiratory tract inflammation.
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Viruses
Infection

Pandemic potential is plentiful, but the next bug’s specifics are known unknown

April 8, 2025
By Anette Breindl
Compared to other forms of prevention, a unique issue for pandemic preparedness is that it is forever unclear what pathogen, exactly, the world needs to be prepared for. There are an estimated 300,000 viruses that infect mammals; add in birds, and the estimate grows to more than half a million. Some of those viruses are much greater threats than others.
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Single strand RNA
Genetic/congenital

Airna’s $155M series B advances RNA editing drug AIR-001 for AATD

April 2, 2025
By Karen Carey
As it prepares to advance its lead RNA editing candidate, AIR-001, into a phase I/II trial for alpha-1 antitrypsin deficiency, Airna Corp. Inc. closed an oversubscribed $155 million series B financing less than a year after completing its series A round. The company, based in Cambridge, Mass., with research operations in Tübingen, Germany, focuses not only on repairing harmful genetic variants found in rare genetic disorders, but also on introducing beneficial variants that improve health in common conditions.
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Respiratory

Biocryst discovers new KLK5 inhibitors

April 1, 2025
Biocryst Pharmaceuticals Inc. has described kallikrein 5 (KLK5; KLK-L2) inhibitors reported to be useful for the treatment of allergy, asthma, cancer, conjunctivitis, dermatological disorders, gastrointestinal conditions, inflammatory disorders and rhinitis, among others.
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Lungs
Respiratory

Financing at Tribune Therapeutics supports targeting CCN protein family to treat fibrosis

March 27, 2025
Tribune Therapeutics AB has raised €37 million (US$40 million) in seed and series A funding to advance a portfolio of therapies targeting central drivers of scar tissue formation.
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