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BioWorld - Saturday, July 19, 2025
Home » Topics » Respiratory, BioWorld Science

Respiratory, BioWorld Science
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Respiratory

Roche describes new NLRP3 inflammasome inhibitors

Feb. 24, 2025
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have identified NLRP3 inflammasome inhibitors reported to be useful for the treatment of asthma, chronic obstructive pulmonary disease and cardiovascular disorders.
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AI generated illustration of lungs in the human body
res

RUNX2-regulated LEPR+ fibroblasts significantly contribute to pathological fibroblasts in fibrosis

Feb. 21, 2025
Researchers from Columbia University Irving Medical Center and collaborators applied unbiased scRNA-seq to study Lepr expression in lung mesenchymal cells. To do that, they used a Lepr(creERT2) mouse model tracing LEPR+ alveolar fibroblasts during neonatal alveologenesis.
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Small extracellular vesicle
Cancer

Clots and metastasis in cancer patients start in the lung

Feb. 20, 2025
By Mar de Miguel
The lung and thrombosis may play a key role in cancer and metastasis progression, according to a collaborative study led by Cornell University scientists. In the nonmetastatic lung microenvironment of several cancer types, the development of a prothrombosis niche promotes metastasis formation through the release of small extracellular vesicles loaded with an integrin protein.
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Novel coronavirus SARS-CoV-2
Infection

KVX-053 alleviates acute lung injury in COVID-19

Feb. 19, 2025
Researchers from Kevirx Inc. and collaborators have described the use of KVX-053, a PTP4A3 inhibitor aimed to be used for the prevention of COVID-19-associated cute lung injury (ALI).
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Respiratory

G-protein coupled receptor kinase is cystic fibrosis target

Feb. 19, 2025
Cystic fibrosis is a life-threatening disease predominantly with respiratory symptoms. Most of the subjects with the disease harbor the F508del variant in the CFTR gene that causes the protein to misfold and be prematurely degraded. Despite approved drugs that restore the CFTR protein, the maximal lung function improvement is approximately 14%.
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Lab glassware and antibodies art concept
Inflammatory

Series A financing at Bambusa to advance bispecific antibodies for immunological and inflammatory disorders

Feb. 17, 2025
Bambusa Therapeutics Inc. has completed an oversubscribed series A financing of approximately $90 million to support its lead programs through phase I trials and advance its pipeline of long-acting bispecific antibodies for immunological and inflammatory disorders.
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Illustration of antibodies binding to human cell receptors
Respiratory

Akeso’s IL-4Rα/ST2 bispecific antibody gains IND clearance in China

Feb. 14, 2025
Akeso Inc. has received IND approval by China’s National Medical Products Administration (NMPA) for AK-139, an IL-4Rα/ST2 bispecific antibody under investigation for a number of indications, including respiratory and skin diseases.
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Immune

Lycia Therapeutics advances protein degradation therapies

Feb. 13, 2025
Lycia Therapeutics Inc. has reported progress in its immunology pipeline that comprises lysosomal targeting chimera (LYTAC)-based protein degradation therapies. The company is advancing its two lead programs toward the clinic: LCA-0061, a Catalytac degrader that catalytically degrades IgE, and LCA-0321, a Lytac degrader designed to specifically bind and rapidly deplete anti-thyroid-stimulating hormone receptor (TSHR) autoantibodies.
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Lungs
Infection

Bioversys identifies optimized lead compounds in BV500 NTM program

Feb. 12, 2025
Bioversys AG has announced that its BV500 NTM program has reached its second milestone with the identification of up to five optimized lead compounds, under the CF AMR Syndicate collaborative discovery program agreement.
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Man with respiratory issues
Respiratory

HMOX1 modulates oxidative stress in upper, lower airway diseases

Feb. 5, 2025
Oxidative stress plays a critical role in the pathogenesis of upper and lower respiratory tract diseases, such as chronic rhinosinusitis with nasal polyps (CRSwNP), allergic rhinitis (AR), and asthma (AS). In the current study, researchers from Huazhong University of Science and Technology and affiliated organizations aimed to assess the role of the essential antioxidant enzyme, heme oxygenase 1 (HMOX1), in these airway diseases.
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