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BioWorld - Friday, March 24, 2023
Home » Topics » Antibody, BioWorld Science

Antibody, BioWorld Science
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3D concept image of nanoparticle layers
Immuno-oncology

Talem Therapeutics collaborates with Libera Bio to develop novel antibodies for use with MPN delivery

March 16, 2023
No Comments
Talem Therapeutics LLC, an independently...
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Antibodies attacking cancer cell
Immuno-oncology

Eureka Therapeutics licenses antibody targeting mesothelin from NCI

March 15, 2023
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Eureka Therapeutics Inc. has entered into a license agreement with the National Cancer Institute (NCI) to develop and commercialize a novel antibody targeting mesothelin (MSLN) in combination with Eureka's proprietary Artemis T-cell receptor platform.
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Coronavirus spike protein
Infection

Exevir Bio reports on anti-S2 camelid single-domain antibody-based drug XRV-013

March 13, 2023
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Exevir Bio BV has announced research detailing a novel, highly potent, anti-S2 camelid single-domain antibody, discovered at the VIB-Ugent Center for Medical Biotechnology, and developed as a candidate drug molecule by Exevir as XVR-013.
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Infection

Autoantibodies against chemokines are possible ally against long COVID

March 7, 2023
By Mar de Miguel
No Comments
Autoantibodies are typically not good news. But a group of researchers from Bellinzona, Switzerland, have observed that the presence of autoantibodies against chemokines, a special class of cytokines, is associated with mild disease and less risk of developing long COVID. “Our hypothesis was that antibodies to chemokines, if they existed, would also be associated with a negative outcome of the disease. But, what we found, in fact, was the exact opposite of what we were predicting,” Davide Robbiani, director of the Institute for Research in Biomedicine, told BioWorld.
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Grizzly bear hunting salmon in river
Immune

Function of mysterious ‘grizzly-like’ macrophage gives insights into autoimmunity

March 3, 2023
By Tamra Sami
No Comments
Even its name is a testament to how enigmatic the tingible macrophage has been. Tingible, which means stainable, certainly gives no clues to its functions – but was, at least, one thing that was known about the cells. Now, scientists at the Garvan Institute of Medical Research have tracked the lifecycle and function of tangible macrophages in the lymph nodes, with implications for understanding autoimmune disorders, which are still poorly understood. Published March 2, 2023, in the journal Cell, the study highlights intravital imaging techniques the scientists used to observe how macrophages formed within the lymph nodes and how they behaved in real time.
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Illustration of ovaries and uterus with endometriosis
Endocrine/Metabolic

Long-lasting effects by ‘recycled’ antibodies improve endometriosis lesions in primate study

March 1, 2023
By Subhasree Nag
No Comments
A multi-institutional team of researchers has reported the development of an anti-IL-8 antibody against endometriosis using recycling antibody engineering technology. The study confirmed the role of the inflammatory cytokine IL-8 in the development of inflammation and fibrosis in endometriosis and showed that administration of IL-8 antibodies in primate models improved endometriosis pathology.
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Illustration of antibodies binding to human cell receptors
Immuno-oncology

Ymmunobio signs transfer ownership agreement for license to NPTXR antibodies

Feb. 1, 2023
No Comments
Ymmunobio AG has secured ownership of neuronal pentraxin receptor (NPTXR) antibodies after the company signed a transfer ownership agreement with Nagoya University for a license to NPTXR antibodies.
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Immuno-oncology

Roquefort's ROQ-A1 and ROQ-A2 Midkine antibody programs demonstrate in vivo safety

Jan. 27, 2023
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Roquefort Therapeutics plc's ROQ-A1 and ROQ-A2 Midkine (MDK) antibody programs, targeting metastatic breast cancer and metastatic lung cancer, have successfully demonstrated in vivo safety in preclinical development programs conducted by cancer research groups.
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Inflammatory

Cantargia completes toxicity study for IL1RAP-binding antibody CAN-10

Jan. 16, 2023
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Cantargia AB has completed a GLP toxicity study for its anti-inflammatory IL1RAP-binding antibody CAN-10, showing that CAN-10 was well tolerated when administered over 6 weeks.
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Lab research with pipette, microsope
Inflammatory

Ono and Monash enter option and research agreement in autoimmune and inflammatory diseases

Jan. 13, 2023
No Comments
Ono Pharmaceutical Co. Ltd. has entered an option and research collaboration agreement with Monash University to discover and develop antibodies targeting G protein-coupled receptors (GPCRs) with the aim of creating novel therapeutics for the treatment of autoimmune and inflammatory diseases.
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