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BioWorld - Tuesday, June 17, 2025
Home » Topics » Antibody, BioWorld Science

Antibody, BioWorld Science
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Obesity, fat cell research concept image
Endocrine/metabolic

Ibio nominates IBIO-610 as obesity development candidate

June 17, 2025
No Comments
Ibio Inc. has nominated IBIO-610 as a development candidate for its first-in-class Activin E antibody program and initiated a nonhuman primate (NHP) study.
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Overweight man sitting on bed facing the window
Endocrine/metabolic

A CD47-blocking antibody ameliorates obesity and enhances exercise capacity

June 11, 2025
No Comments
Obesity is a major public health concern, and effective treatments are still elusive. AMP-activated protein kinase (AMPK) is a crucial regulator of energy homeostasis and has been proposed as a target for metabolic diseases, including obesity. However, most available AMPK agonists target multiple tissues to activate AMPK, which can cause adverse effects.
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Concept art for targeting cancer
Immuno-oncology

AMED funding supports Rakuten’s photoimmunotherapy for malignant epithelial tumors

June 5, 2025
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Rakuten Medical Inc.’s RM-0256 has been selected for funding by Japan’s Agency for Medical Research and Development (AMED).
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Killer T cells surround a cancer cell.
Immuno-oncology

CLN-619 exerts antitumor activity in MICA/B-expressing tumors

May 23, 2025
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Major histocompatibility complex class I-related protein A and B (MICA and MICB) are ligands for the natural killer group 2 member D (NKG2D) receptor and are widely expressed on tumor cells, with very limited expression on normal tissues.
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Antibodies attacking cancer cell
Immuno-oncology

New anti-CCR8 immuno-oncology antibodies with unique binding/pharmacology

May 15, 2025
No Comments
CCR8 is highly expressed on immunosuppressive regulatory T cells (Tregs) in various solid tumors, making it a potential target to enhance antitumor immunity and the efficacy of cancer therapies, including checkpoint inhibitors. However, the impact of CCR8 expression on the Treg phenotype and its role in cancer progression remain unclear.
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Acute myeloid leukemia illustration
Immuno-oncology

The humanized antibody hu128.1 targeting TfR1 shows preclinical potential for erythroleukemia

May 12, 2025
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A recent study explored the therapeutic potential of hu128.1, a humanized antibody targeting transferrin receptor 1 (TfR1), in treating erythroleukemia using xenograft mouse models. The results demonstrate that hu128.1 exerts strong antitumor activity against human erythroleukemic (ERY-1) cells, highlighting its promise as a candidate for managing this aggressive cancer.
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Immuno-oncology

Beigene’s BGB-A3055 inhibits tumor growth in cancer rodent models

May 7, 2025
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Beigene Co. Ltd. has presented data on their anti-CCR8 antibody BGB-A3055 as a cancer immunotherapeutic approach.
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Immuno-oncology

Xenothera details preclinical characterization of XON-9

May 6, 2025
No Comments
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-associated deaths worldwide.
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Antibodies
Immuno-oncology

A single antibody to attack two epitopes for cholangiocarcinoma driven by FGFR2 fusions

April 30, 2025
Abnormal fusion of the FGFR2 gene, encoding the fibroblast growth factor receptor 2, occurs in several types of cancer, including in up to 15% of cases of intrahepatic cholangiocarcinoma.
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Multiple myeloma illustration
Immuno-oncology

QLS-4131 designed to address unmet medical needs in multiple myeloma

April 30, 2025
Multiple myeloma (MM) is a complex disease with poor prognosis and its clinical management still remains a challenge in the field. Since both BCMA and GPRC5D are overexpressed in MM cells, a therapeutic approach targeting both would be of interest. Qilu Pharmaceutical Co. Ltd. is hence developing a dual BCMA- and GPRC5D-targeting antibody – QLS-4131 – for the treatment of MM.
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