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BioWorld - Sunday, July 20, 2025
Home » Topics » Drugs » Antibody

Antibody
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Antibodies
Gastrointestinal

Characterization of DONQ-52, a multispecific antibody against HLA-DQ2.5/gluten peptide complexes

Jan. 9, 2024
Patients with celiac disease have gluten-specific CD4+ T cells that recognize gluten via disease-associated human leukocyte antigen (HLA) molecules, specifically HLA-DQ2.5, leading to immune activation and enteropathy.
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Macrophage and cancer cell
Cancer

Elpiscience and Astellas Pharma enter bispecific macrophage engager collaboration

Dec. 28, 2023
Elpiscience Biopharma Ltd. and Astellas Pharma Inc. have announced a research collaboration and license agreement for two novel bispecific macrophage engagers – ES-019 and another program.
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Antibodies
Immuno-oncology

Biocytogen and Ctm Biotech reach milestone in antibody collaboration

Dec. 28, 2023
Biocytogen Pharmaceuticals Co. Ltd. and Ctm Biotech Co. Ltd. have reported progress in the development of a trispecific T-cell engager for an intracellular target.
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Drug Design, Drug Delivery & Technologies

Ono and Evqlv sign antibody discovery collaboration agreement

Dec. 27, 2023
Ono Pharmaceutical Co. Ltd. has entered into a discovery collaboration agreement with Evqlv Inc. to generate novel antibodies against multiple targets selected by Ono, for the development of innovative antibody drugs.
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SARS-CoV-2 virus particles
Infection

Aerosolized nanobodies broadly neutralize SARS-CoV-2 variants

Dec. 21, 2023
In a study published in Antiviral Research, researchers from the Max Planck Institute for Multidisciplinary Sciences and collaborators have presented optimized nanobodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein.
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3D Rendering of tumor microenvironment
Immuno-oncology

Gilead licenses Compugen’s anti-IL-18 binding protein antibodies to treat cancer

Dec. 20, 2023
Gilead Sciences Inc. has signed an agreement with Compugen Ltd. to exclusively license Compugen’s preclinical antibody program against IL-18 binding protein, including the COM-503 drug candidate. COM-503 is a high affinity antibody which blocks the interaction between IL-18 binding protein and IL-18, thereby inhibiting cancer growth.
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Antibodies illustration
Immune

Strategy to block IgE immunoglobulin release reverses allergy

Dec. 19, 2023
By Mar de Miguel
Scientists at Regeneron Pharmaceuticals Inc. have found a new way to permanently stop allergy through a combination of therapies that prevents the production of antibodies in secondary lymphoid organs and in bone marrow. The approach was tested in vivo in cynomolgus monkeys and in a mouse model.
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Antibodies and red blood cells
Dermatologic

Teva licenses rights to Biolojic's BD9 for atopic dermatitis and asthma

Dec. 15, 2023
Teva Pharmaceutical Industries Ltd. and Biolojic Design Ltd. have announced an exclusive license agreement to develop a potential novel antibody-based therapy for the treatment of atopic dermatitis and asthma.
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Skin, tissue layer illustration
Dermatologic

Scinai Immunotherapeutics reports findings with anti‑IL‑17 VHH antibody in psoriatic human skin model

Dec. 13, 2023
Scinai Immunotherapeutics Ltd. has released promising preclinical results of its innovative anti‑IL‑17 VHH antibody (NanoAb) as a local treatment for mild to moderate plaque psoriasis.
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Endocrine/Metabolic

AdipoRaMab, an AdipoR-activating antibody candidate with efficacy in models of diabetes and NASH

Dec. 7, 2023
Researchers from Mitsubishi Tanabe Pharma Corp. and affiliated organizations have described the discovery and preclinical evaluation of a novel adiponectin receptor (AdipoR)-activating monoclonal antibody, named AdipoRaMab, being developed for the treatment of type 2 diabetes and nonalcoholic steatohepatitis (NASH).
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