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Home » Topics » Drugs » Antibody

Antibody
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Coronavirus spike protein
Infection

Exevir Bio reports on anti-S2 camelid single-domain antibody-based drug XRV-013

March 13, 2023
Exevir Bio BV has announced research detailing a novel, highly potent, anti-S2 camelid single-domain antibody, discovered at the VIB-Ugent Center for Medical Biotechnology, and developed as a candidate drug molecule by Exevir as XVR-013.
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Infection

Autoantibodies against chemokines are possible ally against long COVID

March 7, 2023
By Mar de Miguel
Autoantibodies are typically not good news. But a group of researchers from Bellinzona, Switzerland, have observed that the presence of autoantibodies against chemokines, a special class of cytokines, is associated with mild disease and less risk of developing long COVID. “Our hypothesis was that antibodies to chemokines, if they existed, would also be associated with a negative outcome of the disease. But, what we found, in fact, was the exact opposite of what we were predicting,” Davide Robbiani, director of the Institute for Research in Biomedicine, told BioWorld.
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Grizzly bear hunting salmon in river
Immune

Function of mysterious ‘grizzly-like’ macrophage gives insights into autoimmunity

March 3, 2023
By Tamra Sami
Even its name is a testament to how enigmatic the tingible macrophage has been. Tingible, which means stainable, certainly gives no clues to its functions – but was, at least, one thing that was known about the cells. Now, scientists at the Garvan Institute of Medical Research have tracked the lifecycle and function of tangible macrophages in the lymph nodes, with implications for understanding autoimmune disorders, which are still poorly understood. Published March 2, 2023, in the journal Cell, the study highlights intravital imaging techniques the scientists used to observe how macrophages formed within the lymph nodes and how they behaved in real time.
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Illustration of ovaries and uterus with endometriosis
Endocrine/Metabolic

Long-lasting effects by ‘recycled’ antibodies improve endometriosis lesions in primate study

March 1, 2023
By Subhasree Nag
A multi-institutional team of researchers has reported the development of an anti-IL-8 antibody against endometriosis using recycling antibody engineering technology. The study confirmed the role of the inflammatory cytokine IL-8 in the development of inflammation and fibrosis in endometriosis and showed that administration of IL-8 antibodies in primate models improved endometriosis pathology.
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Breaking new ground with knotbodies, Maxion raises $16M

Feb. 15, 2023
By Nuala Moran
Maxion Therapeutics Ltd. has raised $16 million in a series A to take forward a new method for drugging G-protein coupled receptors (GPCRs) and ion channels with antibodies. The technology brings together naturally occurring knottin peptides that are derived from sources such as snake venom and which can engage GPCRs and ion channels, with antibodies that deliver them to these notoriously difficult, shape-shifting targets.
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Illustration of antibodies binding to human cell receptors
Immuno-oncology

Ymmunobio signs transfer ownership agreement for license to NPTXR antibodies

Feb. 1, 2023
Ymmunobio AG has secured ownership of neuronal pentraxin receptor (NPTXR) antibodies after the company signed a transfer ownership agreement with Nagoya University for a license to NPTXR antibodies.
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Immuno-oncology

Roquefort's ROQ-A1 and ROQ-A2 Midkine antibody programs demonstrate in vivo safety

Jan. 27, 2023
Roquefort Therapeutics plc's ROQ-A1 and ROQ-A2 Midkine (MDK) antibody programs, targeting metastatic breast cancer and metastatic lung cancer, have successfully demonstrated in vivo safety in preclinical development programs conducted by cancer research groups.
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Inflammatory

Cantargia completes toxicity study for IL1RAP-binding antibody CAN-10

Jan. 16, 2023
Cantargia AB has completed a GLP toxicity study for its anti-inflammatory IL1RAP-binding antibody CAN-10, showing that CAN-10 was well tolerated when administered over 6 weeks.
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Lab research with pipette, microsope
Inflammatory

Ono and Monash enter option and research agreement in autoimmune and inflammatory diseases

Jan. 13, 2023
Ono Pharmaceutical Co. Ltd. has entered an option and research collaboration agreement with Monash University to discover and develop antibodies targeting G protein-coupled receptors (GPCRs) with the aim of creating novel therapeutics for the treatment of autoimmune and inflammatory diseases.
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Immuno-oncology

Transgene's intravenous IL-12-armed oncolytic virus TG-6050 cleared to enter clinic trials in France

Jan. 9, 2023
Transgene SA has received clinical trial application (CTA) approval from the French National Agency for the Safety of Medicines and Health Products (ANSM) to proceed with a phase I trial of TG-6050, a novel oncolytic virus (OV) for intravenous administration in patients with advanced non-small-cell lung cancer (NSCLC). Enrollment is expected to open in the first half of this year.
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