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Home » Topics » Drugs » Antibody

Antibody
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Hematologic

NVG-444, a potent next-generation FVIII mimetic antibody with self-regulating mechanism

Feb. 10, 2025
At the recent annual congress of the European Association for Haemophilia and Allied Disorders, researchers from Novalgen Ltd. presented the discovery and preclinical characterization NVG-444, a potentially first-in-class next-generation FVIII mimetic antibody equipped with autoregulation to reduce prothrombotic risks that is being developed for the treatment of hemophilia A.
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Lung cancer illustration
Immuno-oncology

Bifunctional antibody JS-201 shows synergistic antitumor effects in cancer

Feb. 3, 2025
Chinese researchers and their collaborators have published data on the bifunctional antibody JS-201, which exerts dual targeting of PD-1 and TGF-β signaling, for the potential treatment of cancer and its protective role against radiation-induced lung injury.
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Photo of bird, H5N1 virus
Infection

Antibody prevents severe bird flu in macaques

Feb. 3, 2025
By Mar de Miguel
Scientists at the University of Pittsburgh have tested a broadly neutralizing antibody that binds the stem of a protein against H5N1 avian influenza, which prevented severe disease in nonhuman primates and was effective for at least 8 weeks. The scientists remark on the potential of the design developed by Astrazeneca plc against a possible outbreak of the influenza A virus.
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Antibodies attacking cancer cell
Immuno-oncology

CPRIT funding supports Ypsilon’s TCRm antibodies

Jan. 31, 2025
Ypsilon Therapeutics has been awarded $2.7 million in seed funding from Cancer Prevention & Research Institute of Texas (CPRIT). The award will allow Ypsilon to advance its lead therapeutic program, a next-generation T-cell receptor mimic (TCRm) antibody, to drug candidate nomination, with the aim of developing treatments for patients with solid tumors, such as triple-negative breast cancer, non-small-cell lung cancer and gastric cancer.
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3d rendering of bispecific antibodies

Newco Prolium licenses antibody from Innocare, Keymed for $520M

Jan. 21, 2025
By Tamra Sami
In another Chinese newco out-licensing deal, Innocare Pharma Ltd. and Keymed Biosciences Co. Ltd. out-licensed their co-developed CD20×CD3 bispecific antibody (ICP-B02/CM355) to startup Prolium Bioscience Inc. in a deal worth up to $520 million.
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Illustration of cell receptors, antibodies

Abbvie and Simcere enter a $1B T-cell engager deal

Jan. 14, 2025
By Lee Landenberger
Abbvie Inc. and Simcere Zaiming Pharmaceutical Co. Ltd. are part of the volley of large deals accompanying the opening of the 43rd annual J.P. Morgan Healthcare Conference in San Francisco. The two have agreed to develop SIM-0500, a humanized GPRC5D-BCMA-CD3 trispecific antibody, which is in phase I studies in the U.S. and China to treat refractory multiple myeloma.
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Illustration of cell receptors, antibodies

Abbvie and Simcere enter a $1B T-cell engager deal

Jan. 13, 2025
By Lee Landenberger
Abbvie Inc. and Simcere Zaiming Pharmaceutical Co. Ltd. are part of the volley of large deals accompanying the opening of the 43rd annual J.P. Morgan Healthcare Conference in San Francisco. The two have agreed to develop SIM-0500, a humanized GPRC5D-BCMA-CD3 trispecific antibody, which is in phase I studies in the U.S. and China to treat refractory multiple myeloma.
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Bladder cancer illustration

Pfizer’s PD-1 inhibitor hits endpoint in BCG-naïve bladder cancer

Jan. 10, 2025
By Jennifer Boggs
Though Pfizer Inc.’s work on a PD-1-targeting antibody has trailed far behind that of its fellow big pharmas, the company could be the first to market in treatment-naïve, high-risk non-muscle invasive bladder cancer on the back of solid phase III data showing subcutaneously administered sasanlimab hit its endpoint of event-free survival. Pfizer anticipates meeting with regulatory agencies to discuss potential filings for what could be the first new treatment for that NMIBC population in decades.
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Illustration of myocytes
Endocrine/metabolic

Ibio licenses long-acting anti-myostatin antibody from Astralbio

Jan. 7, 2025
Ibio Inc. has expanded its cardiometabolic and obesity treatment development program by in-licensing a long-acting anti-myostatin antibody from Astralbio Inc. The antibody, now named IBIO-600, was identified by Astralbio using Ibio’s proprietary technology stack.
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Bioarctic, Bristol Myers join efforts in $1.35B Alzheimer’s deal

Dec. 23, 2024
By Karen Carey
In a deal worth $100 million up front and up to $1.25 billion in milestone payments, Bioarctic AB licensed its pyroglutamate-amyloid-β (pyroglutamate-Aβ) antibody program to Bristol Myers Squibb Co. to advance treatments for Alzheimer’s disease.
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