As life begins to return to a semblance of normal in many parts of the world, COVAX cautioned countries July 1 against adopting policies that favor specific COVID-19 vaccines.

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Allogene, Direct, Emergex, Lexeo, Solasia.

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Addex, Aimmune, Amyris, Apellis, Beam, Bioasis, Biophytis, Arthrex, Celularity, Codagenix, Constellation, Cyxone, Endo, Entasis, Flugen, Hermes, Merck, Morphosys, Nant Africa, Nestlé, NGM, Orchard, Oxyrane, Oyster Point, Pharming, Quanta, Seres, TLC, Xbiotech.

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Adocia, Alnylam, Altimmune, Angion, Arrowhead, Atea, Axcella, Bone, Brickell, Compugen, Cynata, Cytokinetics, Diffusion, Embera, Gensight, Histogen, International Stem Cell, Lyra, Madrigal, Meissa, NMD, Novome, Oasmia, Ocuphire, Pharmajet, Retrotope, Saniona, Sellas, Sinovac, Sirnaomics, United, Vedanta.

Shares in Altimmune Inc. and Angion Biomedica Corp. were sharply down after the companies announced trial disappointments from a nasal COVID-19 vaccine and two investigational therapies. Altimmune was worst hit, with shares (NASDAQ:ALT) dropping 38% to $9.80 June 30 after announcing its nasal COVID-19 vaccine did not produce enough immune response and axing an immunotherapy trial after encountering problems finding enough subjects.

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: BMS, Catalyst, Chiasma, CNS, Cullinan, Gilead, Hansa, Medexus, Mediwound, Merck, Moderna, Neurogene, Orchard, Palatin, Prilenia, Rafael, Tracon, Vico, Yiling.

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Abcuro, Aditum, Ancora, Alligator, Alpine, Athersys, Bioaegis, Biogen, Cenexi, Clover, Cytovation, Dynavax, Elevation, Enochian, Genomic Testing Cooperative, Glaxosmithkline, ICER, Imaginab, Merck & Co., Nimble, Olimmune, Ose, Rayzebio, Scandion, Scopus, Siga, Taisho, Vir.

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Addex, Astrazeneca, Brim, Celularity, Cerevel, Ciclomed, Compass Pathways, Elicio, F-star, Harmony, Horizon, Iovance, Moderna, Orchard, Pfizer, Propella, Synthetic Biologics, Trillium, VBI.