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BioWorld - Wednesday, October 4, 2023
Home » Topics » Infection » Coronavirus

Coronavirus
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Infection

Arbutus Biopharma presents data on AB-343 for SARS-CoV-2 infection

March 21, 2023
No Comments
For COVID-19, the limited durability of vaccines requires multiple injections, and their effectiveness is continuously challenged by emerging new spike variants of the virus. The SARS-CoV-2 main protease Mpro plays a role in major polyprotein processing events and is essential for viral replication.
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Regulatory actions for March 20, 2023

March 20, 2023
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Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Ipsen, Kuria, Likang, Novartis, Pfizer, Sarepta.
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Paxlovid

Adcom gives thumbs up to Paxlovid, counters rebound myth

March 16, 2023
By Mari Serebrov
No Comments
Citing clinical trial data backed by real-world data, members of the U.S. FDA’s Antimicrobial Drugs Advisory Committee voted overwhelmingly, 16-1, March 16 that the overall benefit-risk assessment is favorable for the use of Pfizer Inc.’s Paxlovid to treat mild to moderate COVID-19 in adults who are at high risk for progression to severe COVID-19, including hospitalization or death.
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Regulatory actions for March 16, 2023

March 16, 2023
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Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Argenx, Biontech, Bioprojet, Cognition, Deciphera, Edesa, Pfizer, Skye.
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In the clinic for March 16, 2023

March 16, 2023
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Clinical updates, including trial initiations, enrollment status and data readouts and publications: Bellicum, Cantargia, Dermavant, Direct, Epicentrx, Evecxia, Horizon, Index, Inhibikase, Mabwell, Oryzon, Oxurion, Protagonist, Recode, Stoke.
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Illustration of coronavirus blocked by the no symbol
Infection

Conjugates of NSAIDs and GS-441524 nucleotide analogue are efficacious against coronaviruses in vivo

March 16, 2023
No Comments
Nucleoside or nucleotide antivirals are a common first-line treatment for viral diseases, acting as direct inhibitors of viral replication and transcription. The nucleoside GS-441524 and its prodrug remdesivir have shown broad-spectrum antiviral activity against several virus families, including Flaviviridae, Filoviridae, Pneumoviridae, paramyxoviruses and Coronaviridae.
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What’s next for Paxlovid

March 15, 2023
By Mari Serebrov
No Comments
Pfizer Inc.’s Paxlovid has become such a part of the COVID-19 treatment scene in the U.S. that it’s easy to forget it’s only authorized for emergency use. That could soon change. The FDA is convening its Antimicrobial Drugs Advisory Committee March 16 to consider Pfizer’s NDA for the co-packaged nirmatrelvir and ritonavir treatment.
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In the clinic for March 15, 2023

March 15, 2023
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Clinical updates, including trial initiations, enrollment status and data readouts and publications: AB, Acesion, Akeso, Astellas, Atea, Biohaven, Cantargia, Endo, Gradalis, Immutep, Medivir, Puma, Reneo, Servier, Telix, Tscan.
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Infection

Pardes Biosciences patents SARS-CoV-2 Mpro inhibitors

March 15, 2023
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Pardes Biosciences Inc. has patented 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of viral infections.
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Coronavirus spike protein
Infection

Exevir Bio reports on anti-S2 camelid single-domain antibody-based drug XRV-013

March 13, 2023
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Exevir Bio BV has announced research detailing a novel, highly potent, anti-S2 camelid single-domain antibody, discovered at the VIB-Ugent Center for Medical Biotechnology, and developed as a candidate drug molecule by Exevir as XVR-013.
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