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BioWorld - Wednesday, October 4, 2023
Home » Topics » Infection » Coronavirus

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Infection

Global Health Drug Discovery Institute describes new SARS-CoV-2 3CLpro inhibitors

Feb. 27, 2023
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Global Health Drug Discovery Institute (GHDDI) has presented 3C-like proteinase (3CLpro) (SARS-CoV-2) inhibitors reported to be useful for the treatment of Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 infections (COVID-19).
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In the clinic for Feb. 24, 2023

Feb. 24, 2023
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Clinical updates, including trial initiations, enrollment status and data readouts and publications: 4D Molecular, Accutar, Amicus, Astellas, Cantargia, Denali, Forge, Horizon, Janssen, Pharmaessentia, Regenxbio, Sangamo, Skye, Theratechnologies, Viiv.
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Infection

Development of recombinant protein vaccines formulated with R-DOTAP

Feb. 24, 2023
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Researchers from PDS Biotechnology Corp. and affiliated organizations have detailed the development and preclinical evaluation of recombinant protein vaccines formulated with enantio-specific cationic lipid R-DOTAP.
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Colorized transmission electron micrograph of SARS-CoV-2.
Infection

Insilico Medicine's 3CLpro inhibitor ISM-3312 cleared to enter clinic in China for COVID-19

Feb. 24, 2023
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Insilico Medicine Inc. has received IND clearance from China's National Medical Products Administration (NMPA) for ISM-3312, an orally available 3CLpro inhibitor for the treatment of COVID-19. ISM-3312 has a novel molecular structure and was optimized from compounds designed by Chemistry42, Insilico’s generative chemistry AI platform.
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Regulatory actions for Feb. 23, 2023

Feb. 23, 2023
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Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Adial, Alimera, Cognition, Erydel, Fapon, GSK, Pfizer, PTC, Sage, Seagen, Viiv, Vir.
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In the clinic for Feb. 23, 2023

Feb. 23, 2023
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Clinical updates, including trial initiations, enrollment status and data readouts and publications: Alteogen, Biomx, Corium, Dare, Grid, Immunic, Immunocore, Jaguar, Kinnate, Linkinvax, Merck & Co., Modus, Shionogi.
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Regulatory actions for Feb. 22, 2023

Feb. 22, 2023
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Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: ABVC, Akebia, Alnylam, Arcutis, Azafaros, Beckley, Biohaven, Biosyngen, Chemomab, Cincor, GC, Icosavax, Kadimastem, Mezzion, Optinose, Orasis, Pfizer, Regeneron, RVAC, Sinovac, Valneva, Vaxcyte.
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In the clinic for Feb. 22, 2023

Feb. 22, 2023
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Clinical updates, including trial initiations, enrollment status and data readouts and publications: Actinium, Aileron, Akari, Ascletis, BMS, Bridge, Effector, Gamida, Ionis, Junshi, Kinarus, Medivir, Merck & Co., Neurophth, Palvella, Pharming, Photocure, Scancell, Takeda, Telix, Westvac.
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Greater horseshoe bats hanging in cave
Infection

Bat cell line reveals unusual molecular relationship with viruses

Feb. 22, 2023
By Helen Albert
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An international team of researchers has created two bat stem cell lines that reveal an unusual number of viral sequences in bat cells compared with those of other mammals. Writing in an article posted online Feb. 21, 2023, in Cell, the scientists suggested that the unusual amount of viral genetic material found in the bat stem cells could explain why these mammals are largely unaffected by most viral infections, despite being able to transmit them.
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Regulatory actions for Feb. 21, 2023

Feb. 21, 2023
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Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Alterity, Apellis, Astellas, Chiesi, CSL, Iveric, Karyopharm, Menarini, Merck, Moderna, Specialised, Teva, Travere, Uniqure.
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