Triple-negative breast cancer (TNBC) still remains as one of the most aggressive breast cancer types among women, with high metastatic potential and ability to shift towards epithelial-mesenchymal transition (EMT).
Scientists from the National Institutes of Health and affiliated organizations established a novel mouse model of intraventricular extension of hemorrhage (IVH) for the purpose of measuring motor and cognitive function in acute and chronic stages of intracerebral hemorrhage, which is the most severe stroke subtype.
Hearing loss related to aging is mostly predicted by the degree of loss of outer hair cells. Investigators from Acousia Therapeutics GmbH have tested the novel Kv7.4 channel activator ACOU-082 in mice.
Researchers from Institut d'Investigacions Biomèdiques August Pi i Sunyer and affiliated organizations have reported the development of novel dual CD19/BCMA CAR T cells, referred to as ARI-0003, developed through co-transduction of two lentiviral vectors encoding CARs targeting CD19 (ARI-0001) and BCMA (ARI-0002h).
Anoctamins are a class of calcium-activated chloride ion channels, which have been recently implicated in cancer pathogenesis. Researchers from Telethon Kids Institute and the University of Western Australia aimed to characterize the expression of the anoctamin family in diffuse midline glioma (DMG).
Undiagnosed bleeding disorders put people at risk due to bleeding without an optimal treatment strategy. Spanish researchers from the Hospital Universitario La Paz and Universidad Autónoma de Madrid have focused on the targeting of tissue factor pathway inhibitor (TFPI) as a potential approach for this medical need by using TFPI blocker antibodies.
The occurrence of acute ischemic stroke impacts the immune landscape in the lungs, leading to peripheral immune activation, which can contribute to cerebral reperfusion injury.
Gray platelet syndrome is an autosomal recessive platelet disorder characterized by macrothrombocytopenia and deficiency or decreased levels of alpha granules that confer a grayish appearance to the platelets. The genetic cause is located at chromosome locus 3p21, affecting the NBEAL2 gene.
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