The University of Michigan has disclosed pyrrolo[1,2-a]-azocine analogues acting as as inhibitor of apoptosis proteins (IAP) inhibitors. As such, they are reported to be potentially useful for the treatment of AIDS, cancer, infections, psoriasis, multiple sclerosis, vascular disorders, inflammatory disorders and autoimmune diseases.
Copper is an essential trace element with critical roles in several biological processes; therefore, its levels are tightly regulated by multiple mechanisms. Researchers from Sun Yat-Sen University (Guangzhou, China) and collaborators recently described the design of a series of novel copper ionophores with varying n-alkyl chain lengths.
Unlike patients with HER2+ tumors, there is an unmet clinical need for patients with HER2-low expression cancers, which are refractory to trastuzumab. Sanofi SA has developed TPP-45142, a T-cell engager consisting of two nanobody domains targeting HER2 and T-cell receptor (TCR) fused to an Fc region harboring the F234A and L235A mutations to inhibit effector function.
Negio Therapeutics NV has disclosed guanfacine derivatives acting as α2-adrenoceptor agonists. They are reported to be useful for the treatment of cancer.
Nagoya University Graduate School of Medicine (Japan) and collaborating institutions aimed to characterize the heterogeneity of myofibroblastic cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma using the KPC mouse model.
D3 Bio Inc. has obtained IND clearance from the FDA for D3S‑003, enabling initiation of a first‑in‑human phase I trial in patients with advanced solid tumors harboring KRAS G12D mutations.
Idorsia Pharmaceuticals Ltd. and Shanghai Institute of Materia Medica of The Chinese Academy of Sciences have discovered 1,2,3-triazole derivatives acting as L-amino acid oxidase (IL4I1; LAAO) inhibitors designed for use in the treatment of cancer.
Triple-negative breast cancer (TNBC) lacks hormone receptors and HER2 amplification, limiting the effectiveness of targeted therapies and contributing to its aggressive clinical behavior. As aberrant activation of STAT3 is a key driver of TNBC growth, strategies aimed at suppressing STAT3 signaling are emerging as a potential treatment approach.
GT Biopharma Inc. has filed an IND application with the FDA for GTB-5550 TriKE, a B7-H3-targeted natural killer (NK) cell engager for the treatment of B7-H3-expressing solid tumor cancers. Pending approval, the planned phase I basket trial will evaluate GTB-5550 administered subcutaneously in solid tumors.
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