In heart failure, the heart does not oxygenate body tissues adequately. A standard treatment is SGLT2 inhibitors such as empagliflozin and dapagliflozin, derived from the national product phlorizin. However, long-term use of these inhibitors increases risk of renal damage and euglycemic diabetic ketoacidosis.
Tevard Biosciences Inc. has presented new preclinical data on the use of therapeutic suppressor tRNAs (suptRNAs) for the treatment of Duchenne muscular dystrophy (DMD) and dilated cardiomyopathy (DCM). The data show potent restoration of full-length functional proteins in models of DMD and DCM caused by titin truncations (DCM-TTNtv).
Coronary artery bypass graft (CABG) surgery remains the gold standard treatment for patients with severe atherosclerosis, but the long-term failure of the grafted veins is a persistent challenge. Excessive vascular smooth muscle cell (vSMC) proliferation in the grafted tissue, promoted by the increased exposure of vSMCs to pro-inflammatory mediators and cytokines, is a key driver of late CABG failure. A team of researchers from the University of Edinburgh and collaborators previously identified a human-specific long noncoding RNA, named SMILR, that is enriched in vSMC and promotes its proliferation.
KAYO-1732 is a novel, orally available, small-molecule inhibitor of the aldehyde dehydrogenase 1A3 (ALDH1A3) enzyme, being developed for the treatment of type 2 diabetes and cardiovascular disorders.
A new generative AI model trained on UK Biobank data can simultaneously forecast the risks and timing of developing over 1,000 different diseases a decade into the future. The developers applied similar algorithmic concepts to those used to develop large language models like ChatGPT and Gemini to build the model, using medical records from 402,799 participants in UK Biobank.
Mabwell (Shanghai) Bioscience Co. Ltd. and Aditum Bio Management Company LLC have announced the launch of Kalexo Bio, a new company formed in conjunction with an exclusive global license agreement to develop 2MW7141.
Scientists at Gwangju Institute of Science & Technology and JD Bioscience Inc. have disclosed 5-HT2A receptor antagonists reported to be useful for the treatment of cancer, hyperlipidemia, obesity, diabetes, arteriosclerosis, hepatic steatosis, fibrosis and hypertension.
Researchers from the Chinese Academy of Sciences have explored a novel approach using lipid nanoparticles (LNPs) to generate fibroblast activation protein (FAP)-targeted chimeric antigen receptor (CAR) macrophages in vivo and evaluated their potential to mitigate cardiac fibrosis and improve heart function after myocardial ischemia-reperfusion (I/R) injury.
Pulmonary arterial hypertension (PAH) is a condition that may lead to right heart dysfunction. Previous evidence has tied mitochondrial dynamics with the progression of PAH, but the mechanisms behind this are not well elucidated.
Previous studies have shown that neuroinflammation within the brain significantly contributes to the development and progression of hypertension. Neurogenic hypertension is defined as chronically high blood pressure that is initiated and maintained through excessive activity of the sympathetic nervous system, and is associated with increased activation of the kinin B1 receptor (B1R). Moreover, the dysregulation of the kallikrein kinin system and its receptors, particularly B1R, is involved in cardiovascular diseases and other pathological conditions associated with inflammation.
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