Yale University has presented new 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection.

A study published in the July 28, 2022, online edition of Cell Chemical Biology shows that perturbation of thiamine (vitamin B1) metabolism inhibits Pseudomonas aeruginosa growth and sensitizes the bacterium to multiple antibiotics, opening up new avenues for much-needed combination therapies to treat pseudomonal infections.